Type I Antifreeze Proteins Enhance Ice Nucleation above Certain Concentrations

被引：41

作者：

Wilson, Peter W.

Osterday, Katie E. ^{[1
]}

Heneghan, Aaron F. ^{[2
]}

Haymet, Anthony D. J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[2] Univ Wisconsin, Dept Surg, Madison, WI 53792 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 45期

关键词：

LAG-TIME APPARATUS; HETEROGENEOUS NUCLEATION; SUPERCOOLED LIQUIDS; THERMAL HYSTERESIS; AQUEOUS-SOLUTIONS; DEVITRIFICATION; GLYCOPROTEINS; INHIBITION; AGENTS; WATER;

D O I：

10.1074/jbc.M110.171983

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we examined the effects that antifreeze proteins have on the supercooling and ice-nucleating abilities of aqueous solutions. Very little information on such nucleation currently exists. Using an automated lag time apparatus and a new analysis, we show several dilution series of Type I antifreeze proteins. Our results indicate that, above a concentration of similar to 8 mg/ml, ice nucleation is enhanced rather than hindered. We discuss this unexpected result and present a new hypothesis outlining three components of polar fish blood that we believe affect its solution properties in certain situations.

引用

页码：34741 / 34745

页数：5

共 44 条

[1] Janus effect of antifreeze proteins on ice nucleation
Liu, Kai
Wang, Chunlei
Ma, Ji
Shi, Guosheng
Yao, Xi
Fang, Haiping
Song, Yanlin
Wang, Jianjun
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (51) : 14739 - 14744
[2] Molecular recognition of ice by proteins: From ice nucleation to antifreeze
Molinero, Valeria
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[3] Contrasting Behavior of Antifreeze Proteins: Ice Growth Inhibitors and Ice Nucleation Promoters
Eickhoff, Lukas
Dreischmeier, Katharina
Zipori, Assaf
Sirotinskaya, Vera
Adar, Chen
Reicher, Naama
Braslavsky, Ido
Rudich, Yinon
Koop, Thomas
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2019, 10 (05): : 966 - 972
[4] Antifreeze proteins at the Ice/Water interface: Three calculated discriminating properties for orientation of type I proteins
Wierzbicki, Andrzej
Dalal, Pranav
Cheatham, Thomas E., III
Knickelbein, Jared E.
Haymet, A. D. J.
Madura, Jeffry D.
BIOPHYSICAL JOURNAL, 2007, 93 (05) : 1442 - 1451
[5] The effect of antifreeze proteins and poly(vinyl alcohol) on the nucleation of ice: A preliminary study
Holt, CB
CRYOLETTERS, 2003, 24 (05) : 323 - 330
[6] Antifreeze proteins and homogeneous nucleation: On the physical determinants impeding ice crystal growth
Bianco, Valentino
Espinosa, Jorge R.
Vega, Carlos
JOURNAL OF CHEMICAL PHYSICS, 2020, 153 (09):
[7] Preferential Ordering and Organization of Hydration Water Favor Nucleation of Ice by Ice-Nucleating Proteins over Antifreeze Proteins
Aich, Rahul
Pal, Prasun
Chakraborty, Sandipan
Jana, Biman
JOURNAL OF PHYSICAL CHEMISTRY B, 2023, 127 (27): : 6038 - 6048
[8] Structures and ice-binding faces of the alanine-rich type I antifreeze proteins
Patel, Shruti N.
Graether, Steffen P.
BIOCHEMISTRY AND CELL BIOLOGY, 2010, 88 (02) : 223 - 229
[9] Type I 'antifreeze' proteins - Structure-activity studies and mechanisms of ice growth inhibition
Harding, MM
Ward, LG
Haymet, ADJ
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (03): : 653 - 665
[10] Investigations of stereospecifity of binding of type 1 antifreeze proteins to ice
Wierzbicki, A
Taylor, MS
Knight, CA
Madura, JD
Sikes, CS
Harrington, JP
BIOPHYSICAL JOURNAL, 1996, 70 (02) : MP439 - MP439

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