Synthesis of N′-(Quinazolin-4-yl) isonicotinohydrazides and their biological screening, docking and ADME studies

A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DIPEA) under refluxing methanol. All the title molecules were characterized by C-13 NMR, H-1 NMR, Mass and IR spectroscopy. All the compounds were tested for anti-malarial, anti-microbial and anti-tuberculosis activities. They were further tested for the cytotoxic feature. In-silico molecular docking study and ADME properties were also studied for the title molecules. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.