A mannose-6-phosphonate-cholesterylamine conjugate as a specific molecular adhesive linking cancer cells with vesicles

被引：32
作者：
Barragan, V
Menger, FM
Caran, KL
Vidil, C
Morère, A
Montero, JL
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
[2] Univ Montpellier 2, Lab Chim Biomol, UMR 5032, F-34095 Montpellier, France
来源：
CHEMICAL COMMUNICATIONS | 2001年 / 01期
关键词：
D O I：
10.1039/b008446h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hydrolytically stable sugar phosphonate coupled to a steroid via a long and semi-rigid spacer (synthesized via a 12-step sequence) binds both to the mannose-6-phosphonate receptors of certain cancer cells and to the lipid bilayer of vesicles, thereby serving as a multivalent adhesive between cell and vesicle surfaces.
引用
收藏
页码：85 / 86
页数：2
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