Metabolic Alterations in Renal and Prostate Cancer

被引：21

作者：

Ciccarese, Chiara ^{[1
]}

Santoni, Matteo ^{[2
]}

Massari, Francesco ^{[1
]}

Modena, Alessandra ^{[1
]}

Piva, Francesco

Conti, Alessandro

Mazzucchelli, Roberta

Cheng, Liang

Lopez-Beltran, Antonio

Scarpelli, Marina

Tortora, Giampaolo ^{[1
]}

Montironi, Rodolfo

机构：

[1] Univ Verona, Azienda Osped Univ Integrata, Med Oncol, I-37100 Verona, Italy

[2] Polytech Univ Marche, AOU Osped Riuniti, Clin Oncol Med, Ancona, Italy

来源：

CURRENT DRUG METABOLISM | 2016年 / 17卷 / 02期

关键词：

Cancer metabolism; glycolysis; lipogenesis; prostate cancer; renal cell carcinoma; warburg effect; FATTY-ACID SYNTHASE; HYPOXIA-INDUCIBLE FACTORS; TUMOR-SUPPRESSOR PROTEIN; LIPID RAFTS; CELL CARCINOMA; KIDNEY CANCER; EXPRESSION; TARGETS; GROWTH; GENE;

D O I：

10.2174/1389200216666151015112356

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Cancer metabolism is emerging as a promising research area in genitourinary tumors. Both renal cell carcinoma (RCC) and prostate cancer (PCa) cells exhibit marked alterations of their metabolism. These changes include increased aerobic glycolysis (the Warburg effect), increased protein and DNA synthesis and de novo fatty acid (FA) synthesis. Objective: Understanding the molecular mechanisms underlying such alterations will represent a major step forward in cancer research. Indeed, reprogramming cancer cell energy metabolism represents a promising hallmark of cancer and may pave the way for novel personalized approaches. Method: PubMed databases were searched for articles published about cancer metabolism in genitourinary tumors. Results and Conclusion: This review is focused on the metabolic alterations that occur in RCC and PCa and describes the mechanisms underlying such metabolic changes.

引用

页码：150 / 155

页数：6

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