Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer

被引：1
作者：
Sun, Bo [1 ]
Ye, Xiufeng [1 ]
Lin, Li [1 ]
Shen, Mei [2 ]
Jiang, Taotao [2 ]
机构：
[1] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Obstet & Gynecol, Shenzhen 518035, Peoples R China
[2] Anhui Med Univ, Dept Obstet & Gynecol, Hefei 230032, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 01期
关键词：
Cervical cancer; ROR2; prognosis; progression; RECEPTOR TYROSINE KINASE; CARCINOMA; EXPRESSION; WNT-5A;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aims: To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer. Methods: We examined ROR2 levels in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues by real-time PCR. Moreover, we performed immunohistochemistry to examine ROR2 expression in 94 paraffin-embedded cervical cancer samples and analyzed the association between ROR2 expression, clinicopathologic factors and prognosis. Results: ROR2 expression was up-regulated in cervical cancer tissues compared with adjacent normal cervix. In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013). Moreover, survival analysis showed that ROR2 expression was an independent prognostic factor of poor overall and recurrent free survival (P = 0.045 and 0.001, respectively). Conclusion: These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer.
引用
收藏
页码：856 / 861
页数：6
相关论文
共 19 条
[1]   Worldwide burden of cervical cancer in 2008 [J].
Arbyn, M. ;
Castellsague, X. ;
de Sanjose, S. ;
Bruni, L. ;
Saraiya, M. ;
Bray, F. ;
Ferlay, J. .
ANNALS OF ONCOLOGY, 2011, 22 (12) :2675-2686
[2]   Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].
Colombo, N. ;
Carinelli, S. ;
Colombo, A. ;
Marini, C. ;
Rollo, D. ;
Sessa, C. .
ANNALS OF ONCOLOGY, 2012, 23 :27-32
[3]   ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour [J].
Edris, Badreddin ;
Espinosa, Inigo ;
Muehlenberg, Thomas ;
Mikels, Amanda ;
Lee, Cheng-Han ;
Steigen, Sonja E. ;
Zhu, Shirley ;
Montgomery, Kelli D. ;
Lazar, Alexander J. F. ;
Lev, Dina ;
Fletcher, Jonathan A. ;
Beck, Andrew H. ;
West, Robert B. ;
Nusse, Roel ;
van de Rijn, Matt .
JOURNAL OF PATHOLOGY, 2012, 227 (02) :223-233
[4]   The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis [J].
Ford, Caroline E. ;
Ma, Sean Si Qian ;
Quadir, Ashfaque ;
Ward, Robyn L. .
INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (04) :779-787
[5]   Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis [J].
Geng, Ming ;
Cao, Yong-Cheng ;
Chen, Ying-Jian ;
Jiang, Hui ;
Bi, Li-Quan ;
Liu, Xiao-Hong .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (12) :1328-1338
[6]   The C. elegans ROR receptor tyrosine kinase, CAM-1, nonautonomously inhibits the Wnt pathway [J].
Green, Jennifer L. ;
Inoue, Takao ;
Sternberg, Paul W. .
DEVELOPMENT, 2007, 134 (22) :4053-4062
[7]   Cancer burden in Africa and opportunities for prevention [J].
Jemal, Ahmedin ;
Bray, Freddie ;
Forman, David ;
O'Brien, Meg ;
Ferlay, Jacques ;
Center, Melissa ;
Parkin, D. Maxwell .
CANCER, 2012, 118 (18) :4372-4384
[8]   Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer [J].
Lara, Ester ;
Calvanese, Vincenzo ;
Huidobro, Covadonga ;
Fernandez, Agustin F. ;
Moncada-Pazos, Angela ;
Obaya, Alvaro J. ;
Aguilera, Oscar ;
Manuel Gonzalez-Sancho, Jose ;
Sanchez, Laura ;
Astudillo, Aurora ;
Munoz, Alberto ;
Lopez-Otin, Carlos ;
Esteller, Manel ;
Fraga, Mario F. .
MOLECULAR CANCER, 2010, 9
[9]   Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2 [J].
Li, Changgong ;
Chen, Hongyan ;
Hu, Lingyan ;
Xing, Yiming ;
Sasaki, Tomoyo ;
Villosis, Maria F. ;
Li, John ;
Nishita, Michiru ;
Minami, Yasuhiro ;
Minoo, Parviz .
BMC MOLECULAR BIOLOGY, 2008, 9
[10]   Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma [J].
Lu, Bei-Ji ;
Wang, Yun-Qing ;
Wei, Xue-Jie ;
Rong, Liang-Qun ;
Wei, Dong ;
Yan, Chang-Ming ;
Wang, Deng-Jie ;
Sun, Jun-Ying .
MOLECULAR MEDICINE REPORTS, 2012, 5 (04) :1033-1036
12