An improved large scale synthesis of the Schollkopf chiral auxiliaries:: (2R)- and (2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine

被引：26

作者：

Chen, JX ^{[1
]}

Corbin, SP ^{[1
]}

Holman, NJ ^{[1
]}

机构：

[1] Albany Mol Res Inc, Syracuse Res Ctr, N Syracuse, NY 13212 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1021/op049777t

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Syntheses of the Schollkopf chiral auxiliaries have been carried out on large scale in high overall yields from D- and L-valine. This method avoids the use of highly toxic phosgene or triphosgene, low-temperature reactions, and unstable intermediates.

引用

页码：185 / 187

页数：3

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