A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

被引：19

作者：

Jenkins, NE

Mwangi, TW

Kortok, M

Marsh, K

Craig, AG

Williams, TN

机构：

[1] Univ Liverpool Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[2] Ctr Geog Med Res, Wellcome Trust Programme, Kenya Med Res Inst, Kilifi, Kenya

[3] John Radcliffe Hosp, Nuffield Dept Med, Oxford, England

[4] John Radcliffe Hosp, Dept Paediat, Oxford OX3 9DU, England

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 41卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1086/498156

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

引用

收藏

页码：1817 / 1819

页数：3

相关论文

共 12 条

[1] Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population [J].

Bellamy, R ;

Kwiatkowski, D ;

Hill, AVS .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1998, 92 (03) :312-316

[2] Bacteremia among children admitted to a rural hospital in Kenya [J].

Berkley, JA ;

Lowe, BS ;

Mwangi, I ;

Williams, T ;

Bauni, E ;

Mwarumba, S ;

Ngetsa, C ;

Slack, MPE ;

Njenga, S ;

Hart, CA ;

Maitland, K ;

English, M ;

Marsh, K ;

Scott, JAG .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (01) :39-47

[3] The role of ICAM-1 in Plasmodium falciparum cytoadherence [J].

Chakravorty, SJ ;

Craig, A .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2005, 84 (01) :15-27

[4] A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi) [J].

Craig, A ;

Fernandez-Reyes, D ;

Mesri, M ;

McDowell, A ;

Altieri, DC ;

Hogg, N ;

Newbold, C .

HUMAN MOLECULAR GENETICS, 2000, 9 (04) :525-530

[5] A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya [J].

FernandezReyes, D ;

Craig, AG ;

Kyes, SA ;

Peshu, N ;

Snow, RW ;

Berendt, AR ;

Marsh, K ;

Newbold, CI .

HUMAN MOLECULAR GENETICS, 1997, 6 (08) :1357-1360

[6] Lymphocyte migration into the central nervous system: Implication of ICAM-1 signalling at them blood-brain barrier [J].

Greenwood, J ;

Etienne-Manneville, S ;

Adamson, P ;

Couraud, PO .

VASCULAR PHARMACOLOGY, 2002, 38 (06) :315-322

[7] Association of the ICAM-1Kilifi mutation with protection against severe malaria in Lambarene, Gabon [J].

Kun, JFJ ;

Klabunde, J ;

Lell, B ;

Luckner, D ;

Alpers, M ;

May, J ;

Meyer, C ;

Kremsner, PG .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (05) :776-779

[8] Lymphocyte function antigen-1 mediates leukocyte adhesion and subsequent liver damage in endotoxemic mice [J].

Li, X ;

Klintman, D ;

Weitz-Schmidt, G ;

Schramm, R ;

Thorlacius, H .

BRITISH JOURNAL OF PHARMACOLOGY, 2004, 141 (04) :709-716

[9] Adhesion molecule polymorphisms in chronic renal allograft failure [J].

McLaren, AJ ;

Marshall, SE ;

Haldar, NA ;

Mullighan, CG ;

Fuggle, SV ;

Morris, PJ ;

Welsh, KI .

KIDNEY INTERNATIONAL, 1999, 55 (05) :1977-1982

[10] Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya [J].

Mwangi, TW ;

Ross, A ;

Snow, RW ;

Marsh, K .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (11) :1932-1939