thrombosis;
atherosclerosis;
platelet aggregation;
high density lipoprotein;
oxidative stress;
hypochlorite;
D O I:
10.1016/j.febslet.2008.02.001
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
High density lipoproteins (HDL) represent a protective factor of central importance that counteracts the development of cardiovascular disease, in part by normalizing platelet (hyper)reactivity. As HDL represent an efficient scavenger of the naturally occurring oxidant hypochlorite, this work was intended to investigate the influence of hypochlorite-oxidized HDL on platelet function. Addition of hypochlorite-oxidized HDL to human platelets results in an immediate and transient raise in intracellular calcium, surface expression of P-selectin and platelet aggregation. The observed effects are dose dependent and can be blocked by an antibody directed against the lipoprotein-binding domain of platelet thrombospondin- and scavenger receptor CD36. (c) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA
Ansell, Benjamin J.
Fonarow, Gregg C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA
Fonarow, Gregg C.
Fogelman, Alan M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA
Ansell, Benjamin J.
Fonarow, Gregg C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA
Fonarow, Gregg C.
Fogelman, Alan M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Atherosclerosis Res Unit,Div Cardiol, Los Angeles, CA USA