Molecular imaging of brain tumors with 18F-DOPA PET and PET/CT

被引：28
作者：
Calabria, Ferdinando [1 ]
Chiaravalloti, Agostino [3 ]
Di Pietro, Barbara [3 ]
Grasso, Cristina [2 ]
Schillaci, Orazio [1 ,3 ]
机构：
[1] IRCCS Neuromed, Dept Nucl Med & Mol Imaging, I-86077 Pozzilli, IS, Italy
[2] IRCCS Neuromed, Dept Neuroradiol, I-86077 Pozzilli, IS, Italy
[3] Univ Roma Tor Vergata, Dept Biopathol & Diagnost Imaging, Rome, Italy
来源：
NUCLEAR MEDICINE COMMUNICATIONS | 2012年 / 33卷 / 06期
关键词：
brain metastases; brain tumors; F-18]-L-dihydroxyphenylalanine; molecular imaging; PET/CT; recurrence; POSITRON-EMISSION-TOMOGRAPHY; GLIOBLASTOMA-MULTIFORME; RADIATION NECROSIS; F-18-FDOPA PET; F-18; FDG; GRADE; PET/MRI; GLIOMAS; FLT;
D O I：
10.1097/MNM.0b013e328351d566
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The objective of this study was to give an overview of the potential clinical utility of [F-18]-L-dihydroxyphenylalanine (F-18-DOPA) PET and PET/CT for imaging of brain tumors. Review articles and reference lists were used to supplement the search findings. F-18-DOPA has been investigated as a PET tracer for primary brain tumors, metastases of somatic cancer, and evaluation of relapse of pathology in patients with brain tumor after surgery and/or radiotherapy on the basis of enhanced cell proliferation. Available studies have provided encouraging preliminary results for diagnosis of brain tumors and relapse after surgery/radiotherapy. In the brain, excellent discrimination between tumor and normal tissue can be achieved because of he low physiological uptake of F-18-DOPA and the high ratio between tumor and normal hemispheric tissue. Information on evaluation of brain metastases is limited but encouraging. PET and PET/CT with F-18-DOPA are useful in diagnosing primary brain tumors and should be recommended in the diagnosis of relapse of disease after surgical treatment and/or radiotherapy. Semiquantitative analysis could improve diagnosis while correlative imaging with MRI is essential. Limits are due to low knowledge of potential pitfalls. Nucl Med Commun 33:563-570 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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页码：563 / 570
页数：8
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