Acute-phase response reactants as objective biomarkers of radiation-induced mucositis in head and neck cancer

被引：21
|
作者：
Mohammed, Fazilat F. [1 ]
Poon, Ian [1 ]
Zhang, Liying [1 ]
Elliott, Liz [2 ]
Hodson, Ian D. [2 ]
Sagar, Stephen M. [2 ]
Wright, James [2 ]
机构：
[1] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada
[2] McMaster Univ, Juravinski Canc Ctr, Hamilton, ON, Canada
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 07期
关键词：
ESR; CRP; head and neck cancer; mucositis; SQUAMOUS-CELL CARCINOMA; C-REACTIVE PROTEIN; PROSPECTIVE RANDOMIZED-TRIAL; THERAPY ONCOLOGY GROUP; LOCALLY ADVANCED HEAD; CONCOMITANT CHEMOTHERAPY; CONCURRENT CHEMOTHERAPY; PREOPERATIVE ELEVATION; ADVANCED LARYNGEAL; ORAL CAVITY;
D O I：
10.1002/hed.21848
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background Current evaluation of radiation-induced mucositis in head and neck cancer relies on subjective scoring with interrater variability. We evaluated serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as objective markers of radiation-induced mucositis. Methods Weekly serum CRP and ESR levels were measured in patients treated for head and neck cancer with radiation +/- chemotherapy. Acute radiation toxicity was evaluated using National Cancer Institute of Canada-Common Toxicity Criteria (NCIC-CTC) version 2.0 and the Head and Neck Radiotherapy Questionnaire (HNRQ). Results ESR and CRP levels were significantly elevated by 3 weeks (p = .01) and 6 weeks (p = .0002), respectively, and independent of age or pretreatment surgery. ESR was significantly dependent on radiation dose (p = .0004) and significantly higher with chemoradiation (p = .03). Conclusion Serum ESR and CRP rise reliably in a radiation dose-dependent manner. ESR correlated with clinical symptoms and distinguished patients receiving chemoradiation. ESR and CRP may be an objective and sensitive marker of radiation-induced mucositis. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012
引用
收藏
页码：985 / 993
页数：9
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