Spatial control of the actin cytoskeleton in Drosophila epithelial cells

被引：106

作者：

Baum, B ^{[1
]}

Perrimon, N ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 10期

关键词：

D O I：

10.1038/ncb1001-883

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The actin cytoskeleton orders cellular space and transduces many of the forces required for morphogenesis. Here we combine genetics and cell biology to identify genes that control the polarized distribution of actin filaments within the Drosophila follicular epithelium. We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex. In contrast, CAP-a Drosophila homologue of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament formation catalysed by Ena at apical cell junctions. The Abl tyrosine kinase also collaborates in this process. We therefore propose that CAP, Ena and Abl act in concert to modulate the subcellular distribution of actin filaments in Drosophila.

引用

页码：883 / 890

页数：8

共 41 条

[1] Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled [J].

Ahern-Djamali, SM ;

Bachmann, C ;

Hua, P ;

Reddy, SK ;

Kastenmeier, AS ;

Walter, U ;

Hoffmann, FM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :4977-4982

[2] Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains [J].

Ahern-Djamali, SM ;

Conner, AR ;

Bachmann, C ;

Kastenmeier, AS ;

Reddy, SK ;

Beckerle, MC ;

Walter, U ;

Hoffmann, FM .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (08) :2157-2171

[3] DEFINING PROTEIN INTERACTIONS WITH YEAST ACTIN IN-VIVO [J].

AMBERG, DC ;

BASART, E ;

BOTSTEIN, D .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (01) :28-35

[4] Proteins of the ADF/cofilin family: Essential regulators of actin dynamics [J].

Bamburg, JR .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :185-230

[5] A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast [J].

Baum, B ;

Li, W ;

Perrimon, N .

CURRENT BIOLOGY, 2000, 10 (16) :964-973

[6] Spatial control of actin filament assembly:: Lessons from Listeria [J].

Beckerle, MC .

CELL, 1998, 95 (06) :741-748

[7] Act up controls actin polymerization to alter cell shape and restrict hedgehog signaling in the Drosophila eye disc [J].

Benlali, A ;

Draskovic, I ;

Hazelett, DJ ;

Treisman, JE .

CELL, 2000, 101 (03) :271-281

[8] Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors [J].

Bilder, D ;

Li, M ;

Perrimon, N .

SCIENCE, 2000, 289 (5476) :113-116

[9]

BRAND AH, 1993, DEVELOPMENT, V118, P401

[10]

Chou TB, 1996, GENETICS, V144, P1673

← 1 2 3 4 5 →