Effect of neoadjuvant chemotherapy on estrogen receptor, progesterone receptor, Cerb-B2, vascular endothelial growth factor and Ki-67 in patients with locally advanced breast cancer

被引：0

作者：

Saritas, Ahmet Gokhan ^{[1
]}

Yalav, Orcun ^{[1
]}

Kekec, Yalcin ^{[1
]}

Sakman, Gurhan ^{[1
]}

Kilic, Emine Bagir ^{[2
]}

Zorludemir, Suzan ^{[2
]}

Ergin, Melek ^{[2
]}

Eray, Tsmail Cem ^{[1
]}

Kara, Tsmail Oguz ^{[3
]}

Paydas, Semra ^{[3
]}

机构：

[1] Cukurova Univ, Fac Med, Dept Gen Surg, Adana, Turkey

[2] Cukurova Univ, Fac Med, Dept Pathol, Adana, Turkey

[3] Cukurova Univ, Fac Med, Dept Med Oncol, Adana, Turkey

来源：

CUKUROVA MEDICAL JOURNAL | 2019年 / 44卷 / 01期

关键词：

Breast cancer; neoadjuvant chemotherapy; VEGF; Ki-67; ER; PR; Cerb-B2; HORMONE-RECEPTORS; EXPRESSION; THERAPY; HER2; MARKERS; ER; CARCINOMA; TUMORS; PR;

D O I：

10.17826/cumj.412192

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: The aim of this study is aimed to demonstrate the changes in the tumor diameter and expressions of vascular endothelial growth factor (VEGF), estrogen receptor (ER), progesterone receptor (PR), Ki-67, and Cerb-B2 status after neoadjuvant chemotherapy in the patients with locally advanced breast cancer. Materials and Methods: Sixty-nine patients who diagnosed with locally advanced breast cancer and treated with were prospectively evaluated. The tumor diameter and VEGF, Ki-67, ER, PR, and Cerb-B2 expressions tested by immunohistochemistry (IHC) were evaluated before and after neoadjuvant chemotherapy. Results: There was a statistically significant reduction in the tumor diameter and in the expression of VEGF, Ki-67, ER, PR, and Cerb-B2 after neoadjuvant chemotherapy. Conclusion: The significant reduction in VEGF expression suggests that the tumor angiogenesis and its metastatic ability may be reduced by neoadjuvant chemotherapy. The significant change in the Ki-67 proliferation index may suggest the reduced proliferative activity of malignant cells with neoadjuvant chemotherapy.

引用

页码：226 / 231

页数：6