Desymmetrization construction of chiral lactones by synergistic Cu(II) complex and organic base

被引：6
作者：
Ali, Murad [1 ]
Li, Changkun [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 29期
基金：
中国国家自然科学基金;
关键词：
Desymmetrization; All-carbon quaternary center; Copper; Lactone; Synergistic catalysis; AZIDE-ALKYNE CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; CATALYZED CYCLIZATION; ACIDS; CYCLOISOMERIZATION;
D O I：
10.1016/j.tetlet.2020.152106
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective construction of quaternary carbon center has been realized by the desymmetrization strategy. Chiral enol lactones with up to 95% ee could be synthesized from prochiral dialkynoic acid under the catalysis of synergistic chiral Cu(II) complex and chiral (DHQ)(2)-PHAL base. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：4
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