Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems

被引：59

作者：

Wan, Chunpeng ^{[1
,2
]}

Yuan, Tao ^{[2
]}

Li, Liya ^{[2
]}

Kandhi, Vamsikrishna ^{[3
]}

Cech, Nadja B. ^{[3
]}

Xie, Mingyong ^{[1
]}

Seeram, Navindra P. ^{[2
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

[2] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA

[3] Univ N Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

关键词：

Acer rubrum; Red maple; Maplexin; Gallotannins; alpha-Glucosidase inhibitory; NATURAL-PRODUCTS; SYRUP; PHYTOCHEMICALS; CONSTITUENTS; PYCNANTHUM; ACERTANNIN; EXTRACTS; LIGNANS; UPDATE; PLANTS;

D O I：

10.1016/j.bmcl.2011.10.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thirteen gallic acid derivatives including five new gallotannins, named maplexins A-E, were isolated from red maple (Acer rubrum) stems. The compounds were identified by spectral analyses. The maplexins varied in number and location of galloyl groups attached to 1,5-anhydro-D-glucitol. The isolates were evaluated for a-glucosidase inhibitory and antioxidant activities. Maplexin E, the first compound identified with three galloyl groups linked to three different positions of 1,5-anhydro-D-glucitol, was 20 fold more potent than the a-glucosidase inhibitory drug, Acarbose (IC50 = 8 vs 160 mu M). Structure-activity related studies suggested that both number and position of galloyls attached to 1,5-anhydro-D-glucitol were important for a-glucosidase inhibition. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：597 / 600

页数：4

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