Acinetobacter baumannii:: Emergence of a successful pathogen

被引：2562
作者：
Peleg, Anton Y. [1 ,2 ]
Seifert, Harald [3 ]
Paterson, David L. [4 ,5 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Cologne, Inst Med Microbiol Immunol & Hyg, D-50935 Cologne, Germany
[4] Univ Queensland, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
[5] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA USA
来源：
CLINICAL MICROBIOLOGY REVIEWS | 2008年 / 21卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1128/CMR.00058-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
引用
收藏
页码：538 / 582
页数：45
相关论文
共 618 条
  • [1] Impact of multi-drug-resistant Acinetobacter baumannii on clinical outcomes
    Abbo, A.
    Carmeli, Y.
    Navon-Venezia, S.
    Siegman-Igra, Y.
    Schwaber, M. J.
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2007, 26 (11) : 793 - 800
  • [2] Multidrug-resistant Acinetobacter baumannii
    Abbo, A
    Navon-Venezia, S
    Orly, HM
    Krichali, T
    Siegman-Igra, Y
    Carmeli, Y
    [J]. EMERGING INFECTIOUS DISEASES, 2005, 11 (01) : 22 - 29
  • [3] Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii
    Afzal-Shah, M
    Woodford, N
    Livermore, DM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (02) : 583 - 588
  • [4] Widespread transfer of resistance genes between bacterial species in an intensive care unit: Implications for hospital epidemiology
    Al Naiemi, N
    Duim, B
    Savelkoul, PHM
    Spanjaard, L
    de Jonge, E
    Bart, A
    Vandenbroucke-Grauls, CA
    de Jong, MD
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) : 4862 - 4864
  • [5] Post-neurosurgical meningitis due to multidrug-resistant Acinetobacter baumanii treated with intrathecal colistin:: Case report and review of the literature
    Al Shirawi, N.
    Memish, Z. A.
    Cherfan, A.
    Al Shimemeri, A.
    [J]. JOURNAL OF CHEMOTHERAPY, 2006, 18 (05) : 554 - 558
  • [6] Alarcon T, 2001, Rev Esp Quimioter, V14, P184
  • [7] Impact of Acinetobacter infection on the mortality of burn patients
    Albrecht, Michael A.
    Griffith, Matthew E.
    Murray, Clinton K.
    Chung, Kevin K.
    Horvath, Edward E.
    Ward, John A.
    Hospenthal, Duane R.
    Holcomb, John B.
    Wolf, Steven E.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2006, 203 (04) : 546 - 550
  • [8] HOSPITAL OUTBREAK OF MULTIRESISTANT ACINETOBACTER-ANITRATUS - AN AIRBORNE MODE OF SPREAD
    ALLEN, KD
    GREEN, HT
    [J]. JOURNAL OF HOSPITAL INFECTION, 1987, 9 (02) : 110 - 119
  • [9] COMMUNITY-ACQUIRED ACINETOBACTER PNEUMONIA IN THE NORTHERN TERRITORY OF AUSTRALIA
    ANSTEY, NM
    CURRIE, BJ
    WITHNALL, KM
    [J]. CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) : 83 - 91
  • [10] Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups
    Anstey, NM
    Currie, BJ
    Hassell, M
    Palmer, D
    Dwyer, B
    Seifert, H
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (02) : 685 - 686
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