Effect of carbon nanotube coating of aligned nanofibrous polymer scaffolds on the neurite outgrowth of PC-12 cells

被引：27

作者：

Jin, Guang-Zhen ^{[1
]}

Kim, Meeju ^{[1
,2
,3
]}

Shin, Ueon Sang ^{[1
]}

Kim, Hae-Won ^{[1
,2
,3
,4
]}

机构：

[1] Dankook Univ, Inst Tissue Regenerat Engn ITREN, Cheonan 330714, South Korea

[2] Dankook Univ, Grad Sch, Dept Nanobiomed Sci, Cheonan 330714, South Korea

[3] Dankook Univ, Grad Sch, WCU Res Ctr, Cheonan 330714, South Korea

[4] Dankook Univ, Sch Dent, Dept Biomat Sci, Cheonan 330714, South Korea

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 07期

关键词：

aligned nanofibre; carbon nanotube; neurite outgrowth; PC-12; cell; PLCL; NEURONAL GROWTH; ELECTROSPUN NANOFIBERS; HIPPOCAMPAL-NEURONS; IN-VITRO; GUIDANCE;

D O I：

10.1042/CBI20100705

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neurite outgrowth from endogenous or transplanted cells is important for neural regeneration following nerve tissue injury. Modified substrates often provide better environments for cell adhesion and neurite outgrowth. This study was conducted to determine if MWCNT (multiwalled carbon nanotube)-coated electrospun PLCL [poly (L-lactic acid-co-3-caprolactone)] nanofibres improved the neurite outgrowth of PC-12 cells. To accomplish this, two groups, PC-12 cells in either uncoated PLCL scaffolds or MWCNT-coated PLCL scaffolds were cultured for 9 days. MWCNT-coated PLCL scaffolds showed improved adhesion, proliferation and neurite outgrowth of PC-12 cells. These findings suggest that MWCNT-coated nanofibrous scaffolds may be an attractive platform for cell transplantation application in neural tissue engineering.

引用

页码：741 / 745

页数：5

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