Evaluation of serum adiponectin levels in diabetic nephropathy

被引:16
作者
Alnaggar, Alshaimaa Rezk L. R. [1 ]
Sayed, Mohamed [1 ]
El-deena, Kareem Essam [1 ]
Gomaa, Mohamed [1 ]
Hamed, Yousra [2 ]
机构
[1] Cairo Univ, Kasr Alainy Hosp, Internal Med Dept, Giza, Egypt
[2] Cairo Univ, New Kasr Alainy Hosp, Giza, Egypt
关键词
Type II diabetes; Microalbuminuria; Diabetic nephropathy; Serum adiponectin; MOLECULAR-WEIGHT ADIPONECTIN; KIDNEY-DISEASE; RENAL-DISEASE; RISK; MORTALITY; DIAGNOSIS;
D O I
10.1016/j.dsx.2018.04.035
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Diabetic nephropathy is one of the major microvascular complications of diabetes mellitus. Adiponectin is an adipose tissue-derived cytokine that was identified in a human adipose tissue cDNA library. Serum adiponectin levels are found to be reduced in various pathological states including obesity, diabetes mellitus, ischaemic heart disease and arteriosclerosis obliterans and elevated in end stage renal diseases. Objective: to assess the level of plasma adiponectin as an early predictor of microvascular complications in patients with type 2 diabetes mellitus. Methods: 44 patients with type 2 diabetes recruited from outpatient diabetes clinic in Kasr Alainy hospital. All patients were subjected to full laboratory work-up including: Fasting blood glucose and Post prandial blood glucose, Glycated haemoglobin A1C, Serum creatinine, Serum total cholesterol, Triglycerides, Low density lipoprotein, High density lipoprotein, C-reactive protein titre, serum adiponectin and Urinary albumin/creatinine (UAC) ratio. Results: The present study demonstrated that serum adiponectin concentrations had significant positive correlation with UAC ratio (r = 0.534, p = 0.0001). Adiponectin levels showed significant positive correlation in patients with diabetes and hypertension with microalbumiuria (p =.001) or normoalbumiuria (p = 0.004). Conclusion: Serum adiponectin level can be a good predictor of diabetic nephropathy in patients with type 2 diabetes mellitus. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:128 / 131
页数:4
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