The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery

被引：16

作者：

Hasegawa, Masahiro ^{[1
]}

Wada, Hideo ^{[2
]}

Miyazaki, Shinichi ^{[1
]}

Yamaguchi, Toshio ^{[1
]}

Wakabayashi, Hiroki ^{[1
]}

Fujimoto, Naoki ^{[2
]}

Matsumoto, Takeshi ^{[3
]}

Ohishi, Kohshi ^{[3
]}

Sakaguchi, Akane ^{[4
]}

Yamada, Norikazu ^{[5
]}

Ito, Masaaki ^{[5
]}

Yamashita, Yoshiki ^{[6
]}

Katayama, Naoyuki ^{[6
]}

Nakatani, Kaname ^{[4
]}

Sudo, Akihiro ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Orthopaed Surg, Tsu, Mie, Japan

[2] Mie Univ, Grad Sch Med, Dept Mol & Lab Med, Tsu, Mie, Japan

[3] Mie Univ, Grad Sch Med, Dept Blood Transfus, Tsu, Mie, Japan

[4] Mie Univ, Grad Sch Med, Cent Lab, Tsu, Mie, Japan

[5] Mie Univ, Grad Sch Med, Dept Cardiol & Nephrol, Tsu, Mie, Japan

[6] Mie Univ, Grad Sch Med, Dept Hematol & Oncol, Tsu, Mie, Japan

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2018年 / 24卷 / 01期

关键词：

VTE; orthopedic surgery; FRMs; D-dimer; FMC; DEEP-VEIN THROMBOSIS; NON-INFERIORITY TRIAL; D-DIMER; PULMONARY-EMBOLISM; TOTAL HIP; PREVENTION; RULE; ARTHROPLASTY; FONDAPARINUX; METAANALYSIS;

D O I：

10.1177/1076029616674824

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated. Materials and Methods: Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE. Results: Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 g/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 g/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 g/mL), and for excluding VTE. Conclusion: Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE.

引用

页码：107 / 114

页数：8

共 29 条

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