The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

被引：230

作者：

Hammouda, Manel B. ^{[1
]}

Ford, Amy E. ^{[1
]}

Liu, Yuan ^{[1
]}

Zhang, Jennifer Y. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Dermatol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

CELLS | 2020年 / 9卷 / 04期

关键词：

JNK; skin inflammation; keratinocytes; BCC; SCC; melanoma; psoriasis; fibrosis; scleroderma; N-TERMINAL KINASE; SQUAMOUS-CELL CARCINOMA; C-JUN; KAPPA-B; PSORIASIS-VULGARIS; CEREBRAL-ISCHEMIA; SCAFFOLD PROTEINS; PEPTIDE INHIBITOR; CRITICAL FEATURES; INDUCED APOPTOSIS;

D O I：

10.3390/cells9040857

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.

引用

页数：22

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