Clinical implications of molecular markers in acute myeloid leukemia

被引：49

作者：

Kayser, Sabine ^{[1
]}

Levis, Mark J. ^{[2
,3
]}

机构：

[1] Univ Hosp Heidelberg, Dept Internal Med V, Heidelberg, Germany

[2] German Canc Res Ctr, Clin Cooperat Unit Mol Hematol Oncol, Heidelberg, Germany

[3] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2019年 / 102卷 / 01期

关键词：

acute myeloid leukemia; molecular markers; prognostic impact; MINIMAL RESIDUAL DISEASE; ACUTE MEGAKARYOBLASTIC LEUKEMIA; INTERNAL TANDEM DUPLICATION; STEM-CELL TRANSPLANTATION; ACUTE PROMYELOCYTIC LEUKEMIA; HIGH-DOSE CYTARABINE; ADDITIONAL CHROMOSOME-ABNORMALITIES; ACUTE MYELOGENOUS LEUKEMIA; TRANS-RETINOIC ACID; LONG-TERM REMISSION;

D O I：

10.1111/ejh.13172

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recently updated World Health Organization (WHO) Classification of myeloid neoplasms and leukemia reflects the fact that research in the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has led to remarkable advances in our understanding of the disease. Gene mutations now allow us to explore the enormous diversity among cytogenetically defined subsets of AML, particularly the large subset of cytogenetically normal AML. Despite the progress in unraveling the tumor genome, only a small number of recurrent mutations have been incorporated into risk-stratification schemes and have been proven to be clinically relevant, targetable lesions. We here discuss the utility of molecular markers in AML in prognostication and treatment decision making, specifically highlighting the aberrations included in the current WHO classification.

引用

页码：20 / 35

页数：16

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