Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

被引：2740
作者：
Supuran, Claudiu T. [1 ]
机构：
[1] Univ Florence, Chim Bioorgan Lab, I-50019 Florence, Italy
来源：
NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 02期
关键词：
D O I：
10.1038/nrd2467
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are involved in numerous physiological and pathological processes, including gluconeogenesis, lipogenesis, ureagenesis, tumorigenicity and the growth and virulence of various pathogens. In addition to the established role of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently emerged that CAIs could have potential as novel anti-obesity, anticancer and anti-infective drugs. Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer's disease. This article discusses the biological rationale for the novel uses of inhibitors or activators of CA activity in multiple diseases, and highlights progress in the development of specific modulators of the relevant CA isoforms, some of which are now being evaluated in clinical trials.
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页码：168 / 181
页数：14
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