The applications of universal DNA base analogues

被引：165
作者：
Loakes, D [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
NUCLEIC ACIDS RESEARCH | 2001年 / 29卷 / 12期
关键词：
D O I：
10.1093/nar/29.12.2437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A universal base analogue forms 'base pairs' with each of the natural DNA/RNA bases with little discrimination between them. A number of such analogues have been prepared and their applications as biochemical tools investigated. Most of these analogues are non-hydrogen bonding, hydrophobic, aromatic 'bases' which stabilise duplex DNA by stacking interactions. This review of the literature of universal bases (to 2000) details the analogues investigated, and their uses and limitations are discussed.
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页码：2437 / 2447
页数：11
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