The dynamic state of protein turnover: It's about time

被引：117
作者：
Hinkson, Izumi V. [1 ]
Elias, Joshua E. [1 ]
机构：
[1] Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA
来源：
TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 05期
基金：
美国国家科学基金会;
关键词：
GENOME-WIDE ANALYSIS; MASS-SPECTROMETRY; DEGRADATIVE RATES; CELL-CULTURE; AMINO-ACIDS; IN-VIVO; LIQUID-CHROMATOGRAPHY; STATISTICAL-MODEL; BODY PROTEINS; HALF-LIFE;
D O I：
10.1016/j.tcb.2011.02.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The continual destruction and renewal of proteins that maintain cellular homeostasis has been rigorously studied since the late 1930s. Experimental techniques for measuring protein turnover have evolved to measure the dynamic regulation of key proteins and now, entire proteomes. In the past decade, the proteomics field has aimed to discover how cells adjust their proteomes to execute numerous regulatory programs in response to specific cellular and environmental cues. By combining classical biochemical techniques with modern, high-throughput technologies, researchers have begun to reveal the synthesis and degradation mechanisms that shape protein turnover on a global scale. This review examines several recent developments in protein turnover research, emphasizing the combination of metabolic labeling and mass spectrometry.
引用
收藏
页码：293 / 303
页数：11
相关论文
共 98 条
[51]   Advances in proteomic workflows for systems biology [J].
Malmstroem, Johan ;
Lee, Hookeun ;
Aebersold, Ruedi .
CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (04) :378-384
[52]   TURNOVER OF PROTEIN IN GROWING AND NON-GROWING POPULATIONS OF ESCHERICHIA-COLI [J].
MANDELSTAM, J .
BIOCHEMICAL JOURNAL, 1958, 69 :110-119
[53]   TURNOVER OF PROTEIN IN STARVED BACTERIA AND ITS RELATIONSHIP TO THE INDUCED SYNTHESIS OF ENZYME [J].
MANDELSTAM, J .
NATURE, 1957, 179 (4571) :1179-1181
[54]   Functional and quantitative proteomics using SILAC [J].
Mann, Matthias .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (12) :952-958
[55]  
MARTIN SJ, 1990, J IMMUNOL, V145, P1859
[56]   THE ACCESSIBLE SURFACE-AREA AND STABILITY OF OLIGOMERIC PROTEINS [J].
MILLER, S ;
LESK, AM ;
JANIN, J ;
CHOTHIA, C .
NATURE, 1987, 328 (6133) :834-836
[57]   PROTEIN TURNOVER IN SKELETAL MUSCLE .1. MEASUREMENT OF RATES OF SYNTHESIS AND CATABOLISM OF SKELETAL MUSCLE PROTEIN USING (C-14) NA2CO3 TO LABEL PROTEIN [J].
MILLWARD, DJ .
CLINICAL SCIENCE, 1970, 39 (05) :577-+
[58]  
MILLWARD DJ, 1971, GUT, V12, P495
[59]   The turnover kinetics of major histocompatibility complex peptides of human cancer cells [J].
Milner, E ;
Barnea, E ;
Beer, I ;
Admon, A .
MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (02) :357-365
[60]  
MOSTELLER RD, 1980, J BIOL CHEM, V255, P2524
12345678910