Mechanisms of Hepatitis B Virus Persistence

被引：188
作者：
Tsai, Kuen-Nan [1 ]
Kuo, Cheng-Fu [1 ]
Ou, Jing-Hsiung James [1 ]
机构：
[1] Univ Southern Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
来源：
TRENDS IN MICROBIOLOGY | 2018年 / 26卷 / 01期
关键词：
E-ANTIGEN; X-PROTEIN; IMMUNE-RESPONSES; HEPATOCELLULAR-CARCINOMA; VIRAL REPLICATION; HUMAN HEPATOCYTES; INTERFERON-ALPHA; PRECORE PROTEIN; CARRIER MOTHERS; INNATE IMMUNITY;
D O I：
10.1016/j.tim.2017.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly one million deaths annually. Studies in recent years have significantly improved our knowledge on the mechanisms of HBV persistence. HBV uses multiple pathways to harness host innate immunity to enhance its replication. It can also take advantage of the developing immune system and the not-yet-stabilized gut microbiota of young children to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offspring to support its persistence after vertical transmission. The knowledge gained from these recent studies paves the way for the development of new therapies for the treatment of chronic HBV infection, which has so far been very challenging.
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收藏
页码：33 / 42
页数：10
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共 70 条
[1]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[2]   The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection [J].
Asabe, Shinichi ;
Wieland, Stefan F. ;
Chattopadhyay, Pratip K. ;
Roederer, Mario ;
Engle, Ronald E. ;
Purcell, Robert H. ;
Chisari, Francis V. .
JOURNAL OF VIROLOGY, 2009, 83 (19) :9652-9662
[3]   Compartmentalized and systemic control of tissue immunity by commensals [J].
Belkaid, Yasmine ;
Naik, Shruti .
NATURE IMMUNOLOGY, 2013, 14 (07) :646-653
[4]   Restoration of HBV-specific CD8+T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation [J].
Bengsch, Bertram ;
Martin, Bianca ;
Thimme, Robert .
JOURNAL OF HEPATOLOGY, 2014, 61 (06) :1212-1219
[5]   Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages [J].
Bility, Moses T. ;
Cheng, Liang ;
Zhang, Zheng ;
Luan, Yan ;
Li, Feng ;
Chi, Liqun ;
Zhang, Liguo ;
Tu, Zhengkun ;
Gao, Yanhang ;
Fu, Yangxin ;
Niu, Junqi ;
Wang, Fusheng ;
Su, Lishan .
PLOS PATHOGENS, 2014, 10 (03)
[6]   THE PRECORE GENE OF THE WOODCHUCK HEPATITIS-VIRUS GENOME IS NOT ESSENTIAL FOR VIRAL REPLICATION IN THE NATURAL HOST [J].
CHEN, HS ;
KEW, MC ;
HORNBUCKLE, WE ;
TENNANT, BC ;
COTE, PJ ;
GERIN, JL ;
PURCELL, RH ;
MILLER, RH .
JOURNAL OF VIROLOGY, 1992, 66 (09) :5682-5684
[7]   A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen [J].
Chen, MT ;
Billaud, JN ;
Sällberg, M ;
Guidotti, LG ;
Chisari, FV ;
Jones, J ;
Hughes, J ;
Milich, DR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (41) :14913-14918
[8]   Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFκB pathway in a human monocytic cell line, THP-1 [J].
Cheng, JD ;
Imanishi, H ;
Morisaki, H ;
Liu, WD ;
Nakamura, H ;
Morisaki, T ;
Hada, T .
JOURNAL OF HEPATOLOGY, 2005, 43 (03) :465-471
[9]   Pathogenesis of hepatitis B virus infection [J].
Chisari, F. V. ;
Isogawa, M. ;
Wieland, S. F. .
PATHOLOGIE BIOLOGIE, 2010, 58 (04) :258-266
[10]   Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota [J].
Chou, Han-Hsuan ;
Chien, Wei-Hung ;
Wu, Li-Ling ;
Cheng, Chi-Hung ;
Chung, Chen-Han ;
Horng, Jau-Haw ;
Ni, Yen-Hsuan ;
Tseng, Hong-Tai ;
Wu, Dafei ;
Lu, Xuemei ;
Wang, Hurng-Yi ;
Chen, Pei-Jer ;
Chen, Ding-Shinn .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (07) :2175-2180
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