The cholinergic hypothesis of cognitive aging revisited again: Cholinergic functional compensation

被引：164

作者：

Dumas, Julie A. ^{[1
]}

Newhouse, Paul A.

机构：

[1] Univ Vermont, Coll Med, Dept Psychiat, Clin Neurosci Res Unit, Burlington, VT 05401 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2011年 / 99卷 / 02期

关键词：

Aging; Cholinergic system; Attention; Memory; Cognitive enhancers; AGE-RELATED-CHANGES; WORKING-MEMORY; ALZHEIMERS-DISEASE; BRAIN ACTIVITY; POSTMENOPAUSAL WOMEN; SELECTIVE ATTENTION; DOUBLE-BLIND; IMPAIRMENT; ENHANCEMENT; SCOPOLAMINE;

D O I：

10.1016/j.pbb.2011.02.022

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

It is now possible to reevaluate the cholinergic hypothesis of age-related cognitive dysfunction based on a synthesis of new evidence from cholinergic stimulation studies and cognitive models. We propose that a change of functional circuitry that can be observed through a combination of pharmacologic challenge and functional neuroimaging is associated with age-related changes in cholinergic system functioning. Psychopharmacological manipulations using cholinergic agonists and antagonists have been consistent in replicating patterns of aging seen in functional imaging studies. In addition, studies of anticholinesterase drugs in patients with Alzheimer's disease and mild cognitive impairment show support for the proposal that cholinergic compensation causes alterations in task-related brain activity. Thus, the cholinergic hypothesis of age-related cognitive dysfunction deserves further consideration as new methodologies for evaluating its validity are increasingly being used. Future directions for testing hypotheses generated from this model are presented. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：254 / 261

页数：8

共 72 条

[1]

[Anonymous], EMBEDDED PROCESSES M

[2]

Bäckman L, 2000, AM J PSYCHIAT, V157, P635

[3] The correlative triad among aging, dopamine, and cognition:: Current status and future prospects [J].

Backman, Lars ;

Nyberg, Lars ;

Lindenberger, Ulman ;

Li, Shu-Chen ;

Farde, Lars .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2006, 30 (06) :791-807

[4] Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging? [J].

Baltes, PB ;

Lindenberger, U .

PSYCHOLOGY AND AGING, 1997, 12 (01) :12-21

[5] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[6] PATTERNS OF MEMORY FAILURE AFTER SCOPOLAMINE TREATMENT - IMPLICATIONS FOR CHOLINERGIC HYPOTHESES OF DEMENTIA [J].

BEATTY, WW ;

BUTTERS, N ;

JANOWSKY, DS .

BEHAVIORAL AND NEURAL BIOLOGY, 1986, 45 (02) :196-211

[7] Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory [J].

Bentley, P ;

Husain, M ;

Dolan, RJ .

NEURON, 2004, 41 (06) :969-982

[8] Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health [J].

Bentley, Paul ;

Driver, Jon ;

Dolan, Ray J. .

BRAIN, 2008, 131 :409-424

[9] Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease? [J].

Benzi, G ;

Moretti, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 346 (01) :1-13

[10] Donepezil for mild cognitive impairment [J].

Birks, J. ;

Flicker, L. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2006, (03)

← 1 2 3 4 5 6 7 8 →