Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru

被引：36

作者：

Baumann, Lauren M. ^{[1
,2
]}

Robinson, Colin L. ^{[1
,2
]}

Combe, Juan M. ^{[2
]}

Gomez, Alfonso ^{[2
]}

Romero, Karina ^{[2
]}

Gilman, Robert H. ^{[2
,3
,4
,5
]}

Cabrera, Lilia ^{[2
]}

Hansel, Nadia N. ^{[1
,6
,7
]}

Wise, Robert A. ^{[1
,7
]}

Breysse, Patrick N. ^{[7
]}

Barnes, Kathleen ^{[1
,6
]}

Hernandez, Juan E. ^{[8
]}

Checkley, William ^{[1
,2
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Div Pulm & Crit Care, Baltimore, MD 21205 USA

[2] AB PRISMA, Lima, Peru

[3] Johns Hopkins Univ, Program Global Dis Epidemiol & Control, Dept Int Hlth, Baltimore, MD 21205 USA

[4] Univ Peruana Cayetano Heredia, Dept Microbiol, Fac Ciencias & Filosofia, Lima, Peru

[5] Univ Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Lima, Peru

[6] Johns Hopkins Sch Med, Div Allergy & Clin Immunol, Baltimore, MD USA

[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA

[8] Inst Nacl Salud Publ, Ctr Informac Decis Salud Publ, Cuernavaca, Morelos, Mexico

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2011年 / 127卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Asthma symptoms; atopy; distance; traffic; particulate matter; spirometry; CHRONIC RESPIRATORY SYMPTOMS; AIR-POLLUTION; ALLERGIC SENSITIZATION; CHILDHOOD ASTHMA; PARTICULATE MATTER; MAJOR HIGHWAY; MAIN ROAD; CHILDREN; EXPOSURE; PREVALENCE;

D O I：

10.1016/j.jaci.2010.11.031

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes. Objective: We sought to determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a periurban shantytown in Lima, Peru. Methods: We enrolled 725 adolescents aged 13 to 15 years who were administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing, and exhaled nitric oxide (eNO). We calculated distances from the main avenue for all households and measured indoor particulate matter in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO levels, and FEV1/forced vital capacity ratio as a function of distance. Results: Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (P < .05). The odds of atopy increased by a factor of 1.07 for every 100-meter difference in the distance from the avenue (P = .03). We found an inverse relationship in prebronchodilator FEV1/forced vital capacity and distance to the avenue in female subjects (P = .01) but not in male subjects. We did not find an association between eNO or household particulate matter levels and distance. Conclusion: Living in close proximity to a high-traffic-density avenue in a periurban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile-source pollutants in periurban areas of developing countries might help reduce the burden of asthma symptoms and atopy. (J Allergy Clin Immunol 2011;127:875-82.)

引用

页码：875 / 882

页数：8