Biologically Active Macrocyclic Compounds - from Natural Products to Diversity-Oriented Synthesis

被引：79

作者：

Madsen, Charlotte M. ^{[1
]}

Clausen, Mads H. ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 17期

关键词：

Natural products; Synthetic methods; Macrocyclization; Diversity-oriented synthesis; Biological activity; ASYMMETRIC TOTAL-SYNTHESIS; RING-CLOSING METATHESIS; MULTICOMPONENT REACTIONS; RAPAMYCIN AY-22,989; ORGANIC-SYNTHESIS; AMPHOTERICIN-B; DISCOVERY; LIBRARY; ERYTHRONOLIDE; ERYTHROMYCIN;

D O I：

10.1002/ejoc.201001715

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrocyclic compounds are attractive targets when searching for molecules with biological activity. The interest in this compound class is increasing, which has led to a variety of methods for tackling the difficult macrocyclization step in their synthesis. This microreview highlights some recent developments in the synthesis of macrocycles, with an emphasis on chemistry developed to generate libraries of putative biologically active compounds.

引用

页码：3107 / 3115

页数：9

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