The interplay between cognition, depression, anxiety, and sleep in primary Sjogren's syndrome patients

被引：23

作者：

Goulabchand, Radjiv ^{[1
,2
,3
]}

Castille, Elodie ^{[2
,4
]}

Navucet, Sophie ^{[5
,6
]}

Etchecopar-Etchart, Damien ^{[7
,8
]}

Matos, Aurelie ^{[5
,6
]}

Maria, Alexandre ^{[2
,3
,4
]}

Gutierrez, Laure Anne ^{[2
,5
,6
]}

Le Quellec, Alain ^{[2
,4
]}

de Champfleur, Nicolas Menjot ^{[9
,10
]}

Gabelle, Audrey ^{[2
,5
,6
]}

Guilpain, Philippe ^{[2
,3
,4
]}

机构：

[1] CHU Nimes, Internal Med Dept, Pl Pr Debre, F-30029 Nimes, France

[2] Univ Montpellier, Montpellier, France

[3] St Eloi Hosp, Inst Regenerat Med & Biotherapy, Inserm U1183, Montpellier, France

[4] Montpellier Univ Hosp, St Eloi Hosp, Dept Internal Med & Multiorgan Dis, Montpellier, France

[5] Montpellier Univ Hosp, Gui de Chauliac Hosp, Memory Res & Resources Alzheimer Ctr, Dept Neurol, Montpellier, France

[6] Univ Montpellier, INSERM, INM, Montpellier, France

[7] Aix Marseille Univ, Fac Med, EA CEReSS Ctr Etud & Rech Serv Sante & Qualite Vi, Sect Timone, Marseille, France

[8] Fdn FonaMental, Creteil, France

[9] Montpellier Univ Hosp, Gui de Chauliac Hosp, Inst Imagerie Fonct Humaine, Dept Neuroradiol,I2FH, Montpellier, France

[10] Univ Montpellier, Lab Charles Coulomb, Montpellier, France

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

QUALITY-OF-LIFE; DISEASE-ACTIVITY; VALIDATION; FATIGUE; PREVALENCE; SEVERITY; AGE;

D O I：

10.1038/s41598-022-17354-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Primary Sjogren's syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patients with memory complaints were included, prospectively. Cognitive profiles were compiled through a comprehensive cognitive evaluation by neuropsychologists. Evaluations of anxiety, depression, fatigue, sleep disorders and quality of life were performed for testing their interactions with cognitive profiles. All 32 pSS patients showed at least borderline cognitive impairment, and 17 (53%) exhibited a pathological cognitive profile: a hippocampal profile (37%), a dysexecutive profile (22%), and an instrumental profile (16%) (possible overlap). Regarding the secondary objectives: 37% of patients were depressed, and 48% exhibited a mild-to-severe anxiety trait. Sleep disorders were frequent (excessive daytime sleepiness (55%), high risk for sleep apnea (45%), and insomnia (77%)). Cognitive impairments could not be explained alone by anxiety, depression or sleep disorders. Fatigue level was strongly associated with sleep disorders. Our study highlights that cognitive complaints in pSS patients are supported by measurable cognitive impairments, apart from frequently associated disorders such as depression, anxiety or sleep troubles. Sleep disorders should be screened.

引用

页数：12

共 71 条

[21]

Deloche G., TEST DENOMINATION OR

[22]

Fauchais Anne-Laure, 2012, Presse Med, V41, pe485, DOI 10.1016/j.lpm.2012.06.002

[23] Patient-evaluated cognitive function measured with smartphones and the association with objective cognitive function, perceived stress, quality of life and function capacity in patients with bipolar disorder [J].