SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review

被引：92

作者：

Fathizadeh, Hadis ^{[1
]}

Afshar, Saman ^{[2
]}

Masoudi, Mahmood Reza ^{[3
]}

Gholizadeh, Pourya ^{[4
]}

Asgharzadeh, Mohammad ^{[5
]}

Ganbarov, Khudaverdi ^{[6
]}

Kose, Sukran ^{[7
]}

Yousefi, Mehdi ^{[8
]}

Kafil, Hossein Samadi ^{[9
]}

机构：

[1] Sirjan Sch Med Sci, Dept Lab Sci, Sirjan, Iran

[2] Univ Tabriz, Fac Nat Sci, Dept Anim Biol, Tabriz, Iran

[3] Sirjan Sch Med Sci, Dept Internal Med, Sirjan, Iran

[4] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[5] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[6] Baku State Univ, Dept Microbiol, Baku, Azerbaijan

[7] Univ Hlth Sci, Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey

[8] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[9] Tabriz Univ Med Sci, Fac Med, Drug Appl Res Ctr, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 188卷

关键词：

Covid-19; Sars-Cov-2; Vaccine; Infection; Adenovirus; Inactivated; Effectiveness; ACUTE RESPIRATORY SYNDROME; ADENOVIRUS TYPE 5; SARS CORONAVIRUS; IMMUNE-RESPONSES; SPIKE PROTEIN; DNA VACCINES; INFECTION; VIRUS; ANTIBODIES; MICE;

D O I：

10.1016/j.ijbiomac.2021.08.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The world has been suffering from COVID-19 disease for more than a year, and it still has a high mortality rate. In addition to the need to minimize transmission of the virus through non-pharmacological measures such as the use of masks and social distance, many efforts are being made to develop a variety of vaccines to prevent the disease worldwide. So far, several vaccines have reached the final stages of safety and efficacy in various phases of clinical trials, and some, such as Moderna/NIAID and BioNTech/Pfizer, have reported very high safety and protection. The important point is that comparing different vaccines is not easy because there is no set standard for measuring neutralization. In this study, we have reviewed the common platforms of COVID-19 vaccines and tried to present the latest reports on the effectiveness of these vaccines.

引用

页码：740 / 750

页数：11

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