Evi-1 expression in Xenopus

被引：14
|
作者：
Mead, PE
Parganas, E
Ohtsuka, S
Morishita, K
Gamer, L
Kuliyev, E
Wright, CVE
Ihle, JN
机构：
[1] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA
[4] Univ Tennessee, Ctr Hlth Sci, Dept Biochem, Memphis, TN 38105 USA
[5] Vanderbilt Univ, Dept Dev & Cell Biol, Dev Biol Program, Nashville, TN 37232 USA
来源：
GENE EXPRESSION PATTERNS | 2005年 / 5卷 / 05期
关键词：
Xenopus laevis; embryogenesis; Evi-1; kidney; brain; neural crest;
D O I：
10.1016/j.modgep.2005.03.007
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：601 / 608
页数：8
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