Evi-1 expression in Xenopus

被引：14

作者：

Mead, PE

Parganas, E

Ohtsuka, S

Morishita, K

Gamer, L

Kuliyev, E

Wright, CVE

Ihle, JN

机构：

[1] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA

[4] Univ Tennessee, Ctr Hlth Sci, Dept Biochem, Memphis, TN 38105 USA

[5] Vanderbilt Univ, Dept Dev & Cell Biol, Dev Biol Program, Nashville, TN 37232 USA

来源：

GENE EXPRESSION PATTERNS | 2005年 / 5卷 / 05期

关键词：

Xenopus laevis; embryogenesis; Evi-1; kidney; brain; neural crest;

D O I：

10.1016/j.modgep.2005.03.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：601 / 608

页数：8

共 14 条

[1] THE STRUCTURE AND EXPRESSION OF THE XENOPUS KROX-20 GENE - CONSERVED AND DIVERGENT PATTERNS OF EXPRESSION IN RHOMBOMERES AND NEURAL CREST [J].