Predictors of clinically significant quality of life impairment in Parkinson's disease

被引：25

作者：

Garcia, Santos D. ^{[1
]}

de Deus Fonticoba, Teresa ^{[2
]}

Cores, Carlos ^{[1
]}

Munoz, Guillermo ^{[1
]}

Paz Gonzalez, Jose M. ^{[1
]}

Martinez Miro, Cristina ^{[1
]}

Suarez, Ester ^{[2
]}

Jesus, Silvia ^{[3
,4
]}

Aguilar, Miquel ^{[5
]}

Pastor, Pau ^{[5
]}

Planellas, Lluis ^{[6
]}

Cosgaya, Marina ^{[7
]}

Garcia Caldentey, Juan ^{[8
]}

Caballol, Nuria ^{[9
]}

Legarda, Ines ^{[10
]}

Hernandez Vara, Jorge ^{[11
]}

Cabo, Iria ^{[12
]}

Lopez Manzanares, Luis ^{[13
]}

Gonzalez Aramburu, Isabel ^{[4
,14
]}

Avila Rivera, Maria A. ^{[15
]}

Catalan, Maria J. ^{[16
]}

Nogueira, Victor ^{[17
]}

Puente, Victor ^{[18
]}

Ruiz de Arcos, Maria ^{[19
]}

Borrue, Carmen ^{[20
]}

Solano Vila, Berta ^{[21
]}

Alvarez Sauco, Maria ^{[22
]}

Vela, Lydia ^{[23
]}

Escalante, Sonia ^{[24
]}

Cubo, Esther ^{[25
]}

Carrillo Padilla, Francisco ^{[26
]}

Martinez Castrillo, Juan C. ^{[27
]}

Sanchez Alonso, Pilar ^{[28
]}

Alonso Losada, Maria G. ^{[29
]}

Lopez Ariztegui, Nuria ^{[30
]}

Gaston, Itziar ^{[31
]}

Clavero, Pedro ^{[31
]}

Kulisevsky, Jaime ^{[4
,32
]}

Blazquez Estrada, Marta ^{[33
]}

Seijo, Manuel ^{[12
]}

Ruiz Martinez, Javier ^{[34
]}

Valero, Caridad ^{[35
]}

Kurtis, Monica ^{[36
]}

de Fabregues, Oriol ^{[11
]}

Gonzalez Ardura, Jessica ^{[37
]}

Ordas, Carlos ^{[38
]}

Lopez Diaz, Luis M. ^{[39
]}

McAfee, Darrian ^{[40
]}

Martinez-Martin, Pablo ^{[4
]}

Mir, Pablo ^{[3
,4
]}

机构：

[1] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain

[2] Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain

[3] Univ Seville, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol Clin,CSIC, Inst Biomed Sevilla,Hosp Univ Virgen del Rocio, Seville, Spain

[4] CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Alava, Spain

[5] Hosp Univ Mutua Terrassa, Barcelona, Spain

[6] Clin Pilar, Neurol, Barcelona, Spain

[7] Hosp Clin Barcelona, Barcelona, Spain

[8] Ctr Neurol Oms 42, Palma De Mallorca, Spain

[9] Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain

[10] Hosp Univ Son Espases, Palma De Mallorca, Spain

[11] Hosp Univ Vall dHebron, Barcelona, Spain

[12] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain

[13] Hosp Univ La Princesa, Madrid, Spain

[14] Hosp Univ Marques de Valdecilla, Santander, Spain

[15] Hosp Gen Hospitalet, Consorci Sanitari Integral, Barcelona, Spain

[16] Hosp Univ Clin San Carlos, Madrid, Spain

[17] Hosp Costa, Lugo, Spain

[18] Hosp del Mar, Barcelona, Spain

[19] Hosp Univ Virgen Macarena, Seville, Spain

[20] Hosp Infanta Sofia, Madrid, Spain

[21] Inst Assistencia Sanitaria IAS, Inst Catala Salut, Girona, Spain

[22] Hosp Gen Univ Elche, Elche, Spain

[23] Fdn Hosp Alcorcon, Madrid, Spain

[24] Hosp Tortosa Verge de la Cinta HTVC, Tarragona, Spain

[25] Complejo Asistencial Univ Burgos, Burgos, Spain

[26] Hosp Univ Canarias, San Cristobal La Laguna, Santa Cruz De T, Spain

[27] Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain

[28] Hosp Univ Puerta de Hierro, Madrid, Spain

[29] Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain

[30] Complejo Hosp Toledo, Toledo, Spain

[31] Complejo Hosp Navarra, Pamplona, Spain

[32] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[33] Hosp Univ Cent Asturias, Oviedo, Spain

[34] Hosp Univ Donostia, San Sebastian, Spain

[35] Hosp Arnau Vilanova, Valencia, Spain

[36] Hosp Ruber Int, Madrid, Spain

[37] Hosp Univ Cabuenes, Gijon, Spain

[38] Hosp Rey Juan Carlos, Madrid, Spain

[39] Complejo Hosp Univ Orense CHUO, Orense, Spain

[40] Univ Penn, Philadelphia, PA 19104 USA

来源：

NPJ PARKINSONS DISEASE | 2021年 / 7卷 / 01期

关键词：

NONMOTOR SYMPTOMS; GENDER-DIFFERENCES; IMPACT; DISABILITY; QUESTIONNAIRE; PROGRESSION; SCALE; DETERMINANTS; VALIDATION; ONSET;

D O I：

10.1038/s41531-021-00256-w

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Quality of life (QOL) plays an important role in independent living in Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months +/- 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 >= 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 +/- 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 +/- 13 to 20.3 +/- 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829-0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422-12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053-1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027-1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer-Lemeshow test, p = 0.665; R-2 = 0.655). An increase in >= 5 and >= 10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663-17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975-22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

引用

页数：10

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