Paracrine properties of Mesenchymal Stromal Cells

Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pathological environment is more related to their ability to modulate the behavior of other cell types than their capacity of differentiation. Recent years have expanded the scope of our knowledge about their way of communication with their environment but also the amount of information that they receive from this environment. In this brief review, we will present some of the mechanisms by which sMSCs can communicate remotely with other cell types and how it currently appears possible to direct the secretion pattern of these cells