Caspases: Enemies within

被引：5989

作者：

Thornberry, NA

Lazebnik, Y

机构：

[1] Merck Res Labs, Dept Biochem, Rahway, NJ 07065 USA

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

SCIENCE | 1998年 / 281卷 / 5381期

关键词：

D O I：

10.1126/science.281.5381.1312

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately Linked to the ability to rationally manipulate apoptosis for therapeutic gain.

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收藏

页码：1312 / 1316

页数：5

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