New Cytotoxic Tigliane Diterpenoids from Croton caudatus

被引：21

作者：

Chen, Ying-Ying ^{[1
,2
]}

Yang, Kun-Xian ^{[3
]}

Yang, Xing-Wei ^{[1
]}

Khan, Afsar ^{[1
,4
]}

Liu, Lu ^{[1
,2
]}

Wang, Bei ^{[1
,2
]}

Zhao, Yun-Li ^{[1
]}

Liu, Ya-Ping ^{[1
]}

Li, Yan ^{[1
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] First People Hosp Yunnan Prov, Kunming, Peoples R China

[4] COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan

来源：

PLANTA MEDICA | 2016年 / 82卷 / 08期

关键词：

Croton caudatus; Euphorbiaceae; tigliane diterpenoid; cytotoxic activity; CHIKUNGUNYA VIRUS-REPLICATION; CLERODANE DITERPENOIDS; PHORBOL; ESTERS; PROSTRATIN; ACTIVATION; INHIBITORS; POTENT; LEAVES; HIV-1;

D O I：

10.1055/s-0042-102539

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new tigliane-type diterpenoids were isolated from the methanolic extract of the twigs and leaves of Croton caudatus, trivially named crotusins A-C (1-3). The structures of compounds 1-3 were elucidated on the basis of extensive spectral methods. These new compounds were highly oxygenated and heavily substituted. Cytotoxic activity against five human tumor cell lines was assessed for compounds 1-3 of which compound 3 showed significant inhibitory activity with IC50 values ranging from 0.49 to 4.19 mu M against these cells, while crotusins A and B exhibited moderate activity.

引用

页码：729 / 733

页数：5

共 33 条

[1]

[Anonymous], 1977, CHINESE SCI BULL, V22, P142

[2] DITERPENE ALCOHOLS FROM CROTON-LACCIFERUS [J].