GLP-2 and leptin are associated with hyperinsulinemia in non-obese female migraineurs

被引：29

作者：

Bernecker, Claudia ^{[1
]}

Pailer, Sabine ^{[1
]}

Kieslinger, Petra ^{[1
]}

Horejsi, Renate ^{[1
]}

Moeller, Reinhard ^{[1
]}

Lechner, Anita ^{[1
]}

Wallner-Blazek, Mirja ^{[1
]}

Weiss, Sabine ^{[1
]}

Fazekas, Franz ^{[1
]}

Truschnig-Wilders, Martini ^{[1
]}

Gruber, Hans-Juergen ^{[1
]}

机构：

[1] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

来源：

CEPHALALGIA | 2010年 / 30卷 / 11期

关键词：

migraine; leptin; GLP-2; insulin; GLUCAGON-LIKE PEPTIDE-1; ADIPOSE-SPECIFIC PROTEIN; BODY-MASS INDEX; INSULIN-RESISTANCE; CELL-PROLIFERATION; ADIPONECTIN; OBESITY; WOMEN; INCREASES; HEADACHE;

D O I：

10.1177/0333102410364674

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Impaired insulin metabolism has been implicated in migraine. However, to date only some putative effects, especially regarding the involvement of adipocytokines and glucagon-like peptides (GLPs), have been described. The aim of the present study was to investigate adipocytokines and GLPs in non-obese female migraineurs. Methods: Various parameters of the insulin metabolism and body measurements were determined in 84 non-obese female subjects. Results: We found highly significantly increased insulin levels with an odds ratio of 10.62 for migraine. Leptin and GLP-2 levels were also increased and correlated with insulin. Logistic regression analysis of leptin and GLP-2 revealed odds ratios of 3.79 and 4.26 for migraine, respectively, when comparing the lowest with the highest quartile of the test variable in the complete study cohort. Discussion: We show that non-obese female migraineurs suffer from hyperinsulinemia, which is associated with elevated leptin and GLP-2 levels. Increased leptin and GLP-2 are risk factors for migraine. Our data suggest that migraine is associated with a higher risk for insulin resistance and its clinical consequences.

引用

页码：1366 / 1374

页数：9

共 51 条

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