Multifunctional protein: cardiac ankyrin repeat protein

被引：13

作者：

Zhang, Na ^{[1
]}

Xie, Xiao-jie ^{[1
]}

Wang, Jian-an ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Cardiovasc Key Lab Zhejiang Prov,Dept Cardiol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2016年 / 17卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Cardiac ankyrin repeat protein (CARP); Cardiovascular disease; Cardiac development; SMOOTH-MUSCLE-CELLS; GENE-EXPRESSION; HEART-FAILURE; DILATED CARDIOMYOPATHY; CARP GENE; HYPERTROPHIC CARDIOMYOPATHY; ECCENTRIC CONTRACTIONS; INDUCED APOPTOSIS; ANKRD1; MUTATIONS; OXIDATIVE STRESS;

D O I：

10.1631/jzus.B1500247

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.

引用

页码：333 / 341

页数：9

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