Novel Apramycin Resistance Gene apmA in Bovine and Porcine Methicillin-Resistant Staphylococcus aureus ST398 Isolates

被引：49
作者：
Fessler, Andrea T. [1 ]
Kadlec, Kristina [1 ]
Schwarz, Stefan [1 ]
机构：
[1] Friedrich Loeffler Inst, Inst Farm Anim Genet, D-31535 Neustadt, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 01期
关键词：
ANTIMICROBIAL RESISTANCE; ESCHERICHIA-COLI; CONFERRING RESISTANCE; FARM-ANIMALS; STRAIN; SWINE; GENTAMICIN; HUMANS; PIGS; IDENTIFICATION;
D O I：
10.1128/AAC.01124-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel apramycin resistance gene, apmA, was detected on the ca.-40-kb resistance plasmid pAFS11 from bovine methicillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 (ST398). The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance. NsiI deletion of apmA resulted in a 16- to 32-fold decrease in the apramycin MICs. An apmA-specific PCR identified this gene in one additional bovine and four porcine MRSA ST398 isolates.
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页码：373 / 375
页数：3
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