Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury

被引：15

作者：

Dabrowski, Wojciech ^{[1
]}

Siwicka-Gieroba, Dorota ^{[1
]}

Robba, Chiara ^{[2
]}

Bielacz, Magdalena ^{[3
]}

Solek-Pastuszka, Joanna ^{[4
]}

Kotfis, Katarzyna ^{[5
]}

Bohatyrewicz, Romuald ^{[4
]}

Jaroszynski, Andrzej ^{[6
]}

Malbrain, Manu L. N. G. ^{[1
,7
,8
]}

Badenes, Rafael ^{[9
]}

机构：

[1] Med Univ Lublin, Dept Anaesthesiol & Intens Care, PL-20954 Lublin, Poland

[2] Policlin San Martino, Dept Anaesthesia & Intens Care, I-16100 Genoa, Italy

[3] State Vocat Coll Szymon Szymonowicz, Inst Tourism & Recreat, PL-22400 Zamosc, Poland

[4] Pomeranian Med Univ, Dept Anaesthesiol & Intens Care, PL-71252 Szczecin, Poland

[5] Pomeranian Med Univ, Dept Anaesthesiol Intens Therapy & Acute Intoxica, PL-70111 Szczecin, Poland

[6] Jan Kochanowski Univ Kielce, Inst Med Sci, Dept Nephrol, PL-25736 Kielce, Poland

[7] Int Fluid Acad, Dreef 3, B-3360 Lovenjoel, Belgium

[8] AZ Jan Palfjin Hosp, Med Dept, Watersportlaan 5, B-9000 Ghent, Belgium

[9] Univ Valencia, Hosp Clin Univ Valencia, Dept Anaesthesiol & Intens Care, Valencia 46010, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 18期

关键词：

osmolality; traumatic brain injury (TBI); hypertonic saline; mannitol; osmolar gap; ACUTE KIDNEY INJURY; BLOOD-BRAIN; OSMOTIC NEPHROSIS; MANNITOL; OSMOLALITY; STRESS; OSMOTHERAPY; RESUSCITATION; AQUAPORINS; ACTIVATION;

D O I：

10.3390/jcm10184141

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperosmotic therapy is commonly used to treat intracranial hypertension in traumatic brain injury patients. Unfortunately, hyperosmolality also affects other organs. An increase in plasma osmolality may impair kidney, cardiac, and immune function, and increase blood-brain barrier permeability. These effects are related not only to the type of hyperosmotic agents, but also to the level of hyperosmolality. The commonly recommended osmolality of 320 mOsm/kg H2O seems to be the maximum level, although an increase in plasma osmolality above 310 mOsm/kg H2O may already induce cardiac and immune system disorders. The present review focuses on the adverse effects of hyperosmolality on the function of various organs.

引用

页数：12

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