Translocation t(7;12) as the sole chromosomal abnormality resulting in ACTB-GLI1 fusion in pediatric gastric pericytoma

被引：36

作者：

Castro, Eumenia ^{[1
]}

Cortes-Santiago, Nahir ^{[2
]}

Ferguson, Lizmery M. Suarez ^{[2
]}

Rao, Pulivarthi H. ^{[3
]}

Venkatramani, Rajkumar ^{[3
]}

Lopez-Terrada, Dolores ^{[2
]}

机构：

[1] Texas Childrens Hosp, Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA

[2] Mol Oncol Lab, Dept Pathol & Immunol, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Baylor Coll Med, Texas Childrens Canc & Hematol Ctr, Dept Pediat, Houston, TX 77030 USA

来源：

HUMAN PATHOLOGY | 2016年 / 53卷

关键词：

Pediatric; Gastric; Tumor; Rare; Translocation; Pericytoma; ACTB;

D O I：

10.1016/j.humpath.2016.02.015

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We hereby report an unusual gastric tumor arising from the pyloric wall of the stomach in a 9-year old child harboring the exceptionally rare translocation t(7;12) resulting in ACTB-GLI1 gene fusion. This tumor has been previously classified as pericytoma with t(7;12) and described in 6 patients, 2 of them children. We discuss the challenges in recognizing this rare entity and the importance of the molecular studies in establishing the correct diagnosis. Our case is the first report of this type arising in the stomach of a child. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：137 / 141

页数：5

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