Overexpression of MARCKS indicates a poor prognosis of oral squamous cell carcinoma

被引:4
|
作者
Li, Chengjing [1 ]
Xia, Rong [1 ]
Xue, Haowei [2 ]
Hu, Yukun [2 ]
Sun, Ming [2 ]
Fang, Dongdong [1 ]
Yang, Wenyu [1 ]
Xiao, Feng [1 ]
Hou, Jun [1 ,2 ]
机构
[1] Anhui Med Univ, Affiliated Hosp 2, Dept Oral & Maxillofacial Surg, Hefei 230001, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Dept Oral & Maxillofacial Surg, 218 Jixi Rd, Hefei 230001, Anhui, Peoples R China
关键词
myristoylated alanine-rich C kinase substrate; oral squamous cell carcinoma; metastasis; proliferation; prognosis; C-KINASE SUBSTRATE; SIGNALING PATHWAY; IN-VIVO; CANCER; PHOSPHORYLATION; GROWTH; PI3K;
D O I
10.3892/ol.2018.9311
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Myristoylated alanine-rich C kinase substrate (MARCKS) is a protein kinase C substrate functioning in different physiological and pathological mechanisms. Previous studies have suggested that MARCKS is capable of influencing tumorigenesis and progression. However, a limited number of studies are available regarding the role of MARCKS in oral squamous cell carcinoma (OSCC). The present study primarily examined MARCKS expression in the OSCC tissues. Furthermore, increased expression of MARCKS was confirmed in the majority of OSCC tissues. Increased MARCKS expression was correlated with more advanced tumor stages, lymphatic metastasis and a poorer overall patient survival. Further molecular mechanistic examinations revealed that downregulated MARCKS expression inhibited the proliferation and migration of OSCC cells in vitro through interruption of MARCKS expression. In addition, the present study demonstrated that MARCKS aggravated OSCC progression via the phosphoinositide 3-kinase/protein kinase B pathway. Accordingly, the present study considered MARCKS to be a promoter of OSCC tumorigenesis and progression, with the potential utility as a biomarker of a poor prognosis.
引用
收藏
页码:5498 / 5504
页数:7
相关论文
共 50 条
  • [41] Overexpression of Platelet-Derived Growth Factor and Its Receptor Are Correlated with Oral Tumorigenesis and Poor Prognosis in Oral Squamous Cell Carcinoma
    Lin, Li-Han
    Lin, Jiun-Sheng
    Yang, Cheng-Chieh
    Cheng, Hui-Wen
    Chang, Kuo-Wei
    Liu, Chung-Ji
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (07)
  • [42] Vav1 expression is increased in esophageal squamous cell carcinoma and indicates poor prognosis
    Zhu, Xiaolei
    Jin, Huan
    Xia, Ziwei
    Wu, Xianxian
    Yang, Mingjian
    Zhang, Hongdian
    Shang, Xiaobin
    Cheng, Runfen
    Zhan, Zhongli
    Yu, Zhentao
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 486 (02) : 571 - 576
  • [43] Notch I Overexpression Associates With Poor Prognosis in Human Laryngeal Squamous Cell Carcinoma
    Li, Dawei
    Dong, Pin
    Wu, Chunping
    Cao, Pengyu
    Zhou, Liang
    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2014, 123 (10): : 705 - 710
  • [44] EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma
    Miyazaki, T
    Kato, H
    Fukuchi, M
    Nakajima, M
    Kuwano, H
    INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (05) : 657 - 663
  • [45] Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
    Hang Zhang
    Wei Chen
    Chao-Jun Duan
    Chun-Fang Zhang
    World Journal of Surgical Oncology, 11
  • [46] Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
    Zhang, Hang
    Chen, Wei
    Duan, Chao-Jun
    Zhang, Chun-Fang
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2013, 11
  • [47] SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma
    Tang, Xia-bing
    Shen, Xiao-hui
    Li, Lei
    Zhang, Yi-fen
    Chen, Guo-qian
    AURIS NASUS LARYNX, 2013, 40 (05) : 481 - 486
  • [48] The overexpression of DBC1 in esophageal squamous cell carcinoma correlates with poor prognosis
    Kim, Seok-Hyung
    Kim, Jeong Hoon
    Yu, Eun Ji
    Lee, Keun-Woo
    Park, Cheol-Keun
    HISTOLOGY AND HISTOPATHOLOGY, 2012, 27 (01) : 49 - 58
  • [49] Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma
    Zhou, Jun-Jie
    Xiao, Yao
    Li, Hao
    Wu, Cong-Cong
    Chen, De-Run
    Chen, Lei
    Deng, Wei-Wei
    Zhang, Wen-Feng
    Sun, Zhi-Jun
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (06): : 799 - 806
  • [50] USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma
    Zhao, Guang-Yin
    Lin, Zong-Wu
    Lu, Chun-Lai
    Gu, Jie
    Yuan, Yun-Feng
    Xu, Feng-Kai
    Liu, Rong-Hua
    Ge, Di
    Ding, Jian-Yong
    TUMOR BIOLOGY, 2015, 36 (03) : 1721 - 1729