The Molecular Mechanisms of Ferroptosis and Its Role in Blood-Brain Barrier Dysfunction

被引：27

作者：

Chen, Xiaoshu ^{[1
]}

Pang, Xinru ^{[1
]}

Yeo, Abrey J. ^{[2
]}

Xie, Siwen ^{[1
]}

Xiang, Mengting ^{[1
]}

Shi, Bin ^{[3
]}

Yu, Gongchang ^{[3
]}

Li, Chao ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Acad Occupat Hlth & Occupat Med, Jinan, Peoples R China

[2] Univ Queensland Ctr Clin Res, Brisbane, Qld, Australia

[3] Shandong First Med Univ & Shandong Acad Med Sci, Neck Shoulder & Lumbocrural Pain Hosp, Jinan, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

基金：

中国国家自然科学基金;

关键词：

ferroptosis; blood brain barrier; iron accumulation; lipid peroxidation; tight junctions; TIGHT JUNCTION PERMEABILITY; ISCHEMIA REPERFUSION INJURY; GLUTATHIONE-PEROXIDASE; 4; INDUCED OXIDATIVE STRESS; FOCAL CEREBRAL-ISCHEMIA; NECROSIS-FACTOR-ALPHA; CELL-DEATH; LIPID-PEROXIDATION; ALZHEIMERS-DISEASE; ENDOTHELIAL-CELLS;

D O I：

10.3389/fncel.2022.889765

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) is a selective, semi-permeable layer of endothelial cells that protects the central nervous system from harmful substances circulating in blood. It is one of the important barriers of the nervous system. BBB dysfunction is an early pathophysiological change observed in nervous system diseases. There are few treatments for BBB dysfunction, so this motivates the review. Ferroptosis is a novel cell death mode caused by iron-mediated lipid peroxidation accumulation, which has recently attracted more attention due to its possible role in nervous system disorders. Studies have shown that lipid peroxidation and iron accumulation are related to the barrier dysfunction, especially the expression of tight junction proteins. Therefore, examination of the relationship between ferroptosis and BBB dysfunction may reveal new targets for the treatment of brain diseases.

引用

页数：13

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