Biomimetic calcium-inactivated ion/molecular channel

被引：13

作者：

Li, Minmin ^{[1
,2
]}

Cao, Yuchen ^{[2
,3
]}

Zhang, Xin ^{[2
]}

Wang, Dongdong ^{[2
]}

Qian, Shengxu ^{[2
]}

Li, Guodong ^{[2
]}

Zhang, Fusheng ^{[2
]}

Xiong, Yuting ^{[1
,2
]}

Qing, Guangyan ^{[2
]}

机构：

[1] East China Univ Technol, Jiangxi Prov Key Lab Polymer Micronano Mfg & Devi, 418 Guanglan Ave, Nanchang 330013, Jiangxi, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China

[3] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 64期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

GATED ION CHANNELS; RECTIFICATION; NANOCHANNELS; TRANSPORT; NANOPORES; BINDING;

D O I：

10.1039/d1cc03058b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A phosphopeptide-modified nanochannel was prepared based on a conical polymeric nanopore. It shows a reversible Ca2+-induced inactivation effect toward the ion flow and molecular transport, resulting from Ca2+ binding-caused surface charge neutralization and hydrophilicity reduction, and Ca2+ removal by the competitive binding.

引用

页码：7914 / 7917

页数：4

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