Cyanidin-3-rutinoside increases glucose uptake by activating the PI3K/Akt pathway in 3T3-L1 adipocytes

被引：31

作者：

Choi, Kyung Ha ^{[1
,2
,3
]}

Lee, Hyun Ah ^{[1
,2
]}

Park, Mi Hwa ^{[3
]}

Han, Ji-Sook ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Dept Food Sci & Nutr, Busan 609735, South Korea

[2] Pusan Natl Univ, Res Inst Ecol Elderly, Busan 609735, South Korea

[3] Silla Univ, Coll Med & Life Sci, Dept Food & Nutr, Busan 616735, South Korea

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2017年 / 54卷

关键词：

Cyanidin-3-rutinoside; Glucose uptake; PI3K/Akt pathway; 3T3-L1; adipocyte; SKELETAL-MUSCLE CELLS; PROTEIN-KINASE; GLUT4; TRANSLOCATION; SIGNALING PATHWAYS; INSULIN; HYPERGLYCEMIA; TRANSPORT; RATS; MICE;

D O I：

10.1016/j.etap.2017.06.007

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In this study, the effect of cyanidin-3-rutinoside (C3R) on glucose uptake by 3T3-L1 adipocytes was studied. C3R significantly increased glucose uptake, which was associated with enhanced plasma membrane glucose transporter type 4 (PM-GLUT4) expression in 3T3-L1 adipocytes. The potentiating effect of C3R on glucose uptake and PM-GLUT4 expression was related to enhanced phosphorylation of insulin receptor substrate 1 (IRS-1) and Akt, as well as augmented activation of phosphatidylinositol-3-kinase (PI3K) in the insulin signaling pathway. C3R induced glucose uptake was inhibited only by the PI3K inhibitor, but not by an AMPK inhibitor in 3T3-L1 adipocytes. Therefore, C3R likely up-regulates glucose uptake and PM-GLUT4 expression in 3T3-L1 adipocytes by activating the PI3K/Akt pathways.

引用

页码：1 / 6

页数：6

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