Fluorofuroxans: Synthesis and Application as Photoinduced Nitric Oxide Donors

被引：21

作者：

Ando, Akihiro ^{[1
]}

Matsubara, Ryosuke ^{[1
]}

Takazawa, Saori ^{[1
]}

Shimada, Toshiyuki ^{[1
]}

Hayashi, Masahiko ^{[1
]}

机构：

[1] Kobe Univ, Dept Chem, Nada Ku, Kobe, Hyogo 6578501, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 07期

关键词：

aromatic substitution; furoxans; nitrogen oxides; photochemistry; synthetic methods; UNSYMMETRICALLY SUBSTITUTED FUROXANS; BIOLOGICAL EVALUATION; GENERATION; FURAZANS; NO; SPECTROSCOPY; SULFONES; RELEASE; ACIDS;

D O I：

10.1002/ajoc.201600149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3- and 4-fluorofuroxans is reported for the first time. Under photoirradiation and physiological conditions, 4-fluorofuroxans with weaker nitric oxide-releasing ability are converted into 3-fluorofuroxans, which show remarkable thiol-mediated nitric oxide-releasing properties, thereby suggesting that 4-fluorofuroxans are potent photoinduced nitric oxide donors.

引用

页码：886 / 890

页数：5

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