Fluorofuroxans: Synthesis and Application as Photoinduced Nitric Oxide Donors

被引：21
作者：
Ando, Akihiro [1 ]
Matsubara, Ryosuke [1 ]
Takazawa, Saori [1 ]
Shimada, Toshiyuki [1 ]
Hayashi, Masahiko [1 ]
机构：
[1] Kobe Univ, Dept Chem, Nada Ku, Kobe, Hyogo 6578501, Japan
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 07期
关键词：
aromatic substitution; furoxans; nitrogen oxides; photochemistry; synthetic methods; UNSYMMETRICALLY SUBSTITUTED FUROXANS; BIOLOGICAL EVALUATION; GENERATION; FURAZANS; NO; SPECTROSCOPY; SULFONES; RELEASE; ACIDS;
D O I：
10.1002/ajoc.201600149
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 3- and 4-fluorofuroxans is reported for the first time. Under photoirradiation and physiological conditions, 4-fluorofuroxans with weaker nitric oxide-releasing ability are converted into 3-fluorofuroxans, which show remarkable thiol-mediated nitric oxide-releasing properties, thereby suggesting that 4-fluorofuroxans are potent photoinduced nitric oxide donors.
引用
收藏
页码：886 / 890
页数：5
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