Calorie restriction effects on circadian rhythms in gene expression are sex dependent

被引：35
作者：
Astafev, Artem A.
Patel, Sonal A.
Kondratov, Roman V. [1 ]
机构：
[1] Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词：
DRUG-METABOLIZING-ENZYMES; MESSENGER-RNA PROFILES; MOUSE-LIVER; LIFE-SPAN; CYP4A ISOFORMS; DNA-DAMAGE; CYTOCHROME-P450; TRANSPORTERS; STRAIN; VASPIN;
D O I：
10.1038/s41598-017-09289-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The rhythms in the expression of circadian clock genes are affected by calorie restriction (CR), a dietary paradigm known to increase lifespan. Many physiological effects of CR differ between males and females; here we investigated if the sex of animals affects the CR induced changes in the circadian rhythms. The liver expression of some circadian clock genes such as Bmal1 and three Periods (Per1, Per2 and Per3) and the effect of CR on the expression of these genes were sex independent, while the expression of Rev-Erb alpha, Ror gamma and both Cryptochome (Cry1 and Cry2) genes was different between males and females. The effect of CR on Rev-Erb alpha, Ror gamma and Cry1 gene expression was sex dependent. The expression and the effects of CR were sex-specific for several genes previously reported to be regulated by CR: Fmo3, Mup4, Serpina12 and Cyp4a12, while the expression of Cyp4a14a was sex independent. IGF signaling plays an important role in aging and CR effects. Igf-1 expression is regulated by CR and by the circadian clock, we found that rhythms in Igf-1 expression have sexual dimorphism. Our data provide molecular evidence that the sex of animals is an important modulator of circadian rhythms in gene expression and their response to CR.
引用
收藏
页数：9
相关论文
共 44 条
[1]   The Circadian Clock Components CRY1 and CRY2 Are Necessary to Sustain Sex Dimorphism in Mouse Liver Metabolism [J].
Bur, Isabelle M. ;
Cohen-Solal, Anne M. ;
Carmignac, Danielle ;
Abecassis, Pierre-Yves ;
Chauvet, Norbert ;
Martin, Agnes O. ;
van der Horst, Gijsbertus T. J. ;
Robinson, Iain C. A. F. ;
Maurel, Patrick ;
Mollard, Patrice ;
Bonnefont, Xavier .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (14) :9066-9073
[2]   Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation [J].
Chaudhari, Amol ;
Gupta, Richa ;
Patel, Sonal ;
Velingkaar, Nikkhil ;
Kondratov, Roman .
MOLECULAR BIOLOGY OF THE CELL, 2017, 28 (06) :834-842
[3]   The Role of Vaspin in the Development of Metabolic and Glucose Tolerance Disorders and Atherosclerosis [J].
Dimova, Rumyana ;
Tankova, Tsvetalina .
BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[4]   Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice [J].
Dubrovsky, Yuliya V. ;
Samsa, William E. ;
Kondratov, Roman V. .
AGING-US, 2010, 2 (12) :936-944
[5]   Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids [J].
Falls, JG ;
Ryu, DY ;
Cao, Y ;
Levi, PE ;
Hodgson, E .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 342 (02) :212-223
[6]   Effect of feeding regimens on circadian rhythms: Implications for aging and longevity [J].
Froy, Oren ;
Miskin, Ruth .
AGING-US, 2010, 2 (01) :7-27
[7]   The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo [J].
Fu, LN ;
Pelicano, H ;
Liu, JS ;
Huang, P ;
Lee, CC .
CELL, 2002, 111 (01) :41-50
[8]   Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice [J].
Fu, Zidong Donna ;
Klaassen, Curtis D. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2014, 274 (01) :137-146
[9]   Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice [J].
Fu, Zidong Donna ;
Csanaky, Ivan L. ;
Klaassen, Curtis D. .
DRUG METABOLISM AND DISPOSITION, 2012, 40 (06) :1216-1225
[10]   Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice [J].
Giller, K. ;
Huebbe, P. ;
Doering, F. ;
Pallauf, K. ;
Rimbach, G. .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2013, 280 (1757)
12345