The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

被引：263

作者：

Goldstein, Tracey ^{[1
,2
]}

Anthony, Simon J. ^{[3
,4
,5
]}

Gbakima, Aiah ^{[6
]}

Bird, Brian H. ^{[1
,2
]}

Bangura, James ^{[6
]}

Tremeau-Bravard, Alexandre ^{[1
,2
]}

Belaganahalli, Manjunatha N. ^{[1
,2
]}

Wells, Heather L. ^{[3
]}

Dhanota, Jasjeet K. ^{[1
,2
]}

Liang, Eliza ^{[3
,5
]}

Grodus, Michael ^{[3
]}

Jangra, Rohit K. ^{[7
]}

DeJesus, Veronica A. ^{[7
]}

Lasso, Gorka ^{[8
]}

Smith, Brett R. ^{[1
,2
]}

Jambai, Amara ^{[9
]}

Kamara, Brima O. ^{[10
]}

Kamara, Sorie ^{[11
]}

Bangura, William ^{[12
]}

Monagin, Corina ^{[1
,2
,13
]}

Shapira, Sagi ^{[8
,14
]}

Johnson, Christine K. ^{[1
,2
]}

Saylors, Karen ^{[13
]}

Rubin, Edward M. ^{[13
]}

Chandran, Kartik ^{[7
]}

Lipkin, W. Ian ^{[3
,4
]}

Mazet, Jonna A. K. ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, One Hlth Inst, Davis, CA 95616 USA

[2] Univ Calif Davis, Sch Vet Med, Karen C Drayer Wildlife Hlth Ctr, Davis, CA 95616 USA

[3] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY 10027 USA

[4] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10027 USA

[5] EcoHlth Alliance, New York, NY 10001 USA

[6] Metabiota Inc, Freetown, Sierra Leone

[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY USA

[8] Columbia Univ, Irving Canc Res Ctr, Dept Syst Biol, New York, NY USA

[9] Minist Hlth & Sanitat, Freetown, Sierra Leone

[10] Minist Hlth & Sanitat, Makeni, Sierra Leone

[11] Minist Agr Forestry & Food Secur, Livestock & Vet Serv Div, Freetown, Sierra Leone

[12] Minist Agr Forestry & Food Secur, Forestry & Wildlife Div, Freetown, Sierra Leone

[13] Metabiota Inc, San Francisco, CA USA

[14] Columbia Univ, Dept Microbiol & Immunol, New York, NY USA

来源：

NATURE MICROBIOLOGY | 2018年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

NIEMANN-PICK C1; OXIDASE-SUBUNIT-I; EBOLA-VIRUS; ENTRY REQUIRES; FRUIT BATS; GLYCOPROTEIN; INFECTION; RECOGNITION; FILOVIRUSES; SEQUENCES;

D O I：

10.1038/s41564-018-0227-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure exposure has actually occurred or if BOMV is pathogenic in humans.

引用

页码：1084 / +

页数：9

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