Anglo American is one of the world's leading mining companies. With operations in over 50 countries and approximately 200 000 permanent employees, its operating profit in 2006 was US$9.8 billion. As well as having financial goals, Anglo American is committed to sustainable development. One of its five sustainable development principles is to 'create meaningful employment in safe, healthy environments'. Its HIV/AIDS programme is part of this effort. Beginning in the mid-1980s with the appointment of an AIDS Education Advisor, the programme was formalized in the early 1990s, and has gained international recognition for its effectiveness and scope. This paper provides an overview of the Anglo American HIV/AIDS programme in southern Africa. Part one outlines the context in which the company works and its reasons for tackling the virus. Part two describes the workplace programme, with a specific focus on Anglo Coal as an example of best practice within the group. Part three looks at the community programme, and the final section discusses the lessons learned. (c) 2007 Lippincott Williams & Wilkins.