Deep brain stimulation of the subthalamic nucleus alters frontal activity during spatial working memory maintenance of patients with Parkinson's disease

被引：12

作者：

Mayer, Jutta S. ^{[1
,2
]}

Neimat, Joseph ^{[3
]}

Folley, Bradley S. ^{[4
]}

Bourne, Sarah K. ^{[3
]}

Konrad, Peter E. ^{[3
]}

Charles, David ^{[5
]}

Park, Sohee ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA

[2] Goethe Univ Frankfurt, Dept Psychol, Frankfurt, Germany

[3] Vanderbilt Univ Sch Med, Dept Neurol Surg, Nashville, TN USA

[4] Norton Neurosci Inst, Louisville, KY USA

[5] Vanderbilt Univ Sch Med, Dept Neurol, Nashville, TN USA

来源：

NEUROCASE | 2016年 / 22卷 / 04期

关键词：

Working memory; deep brain stimulation; Parkinson's disease; functional near-infrared spectroscopy; frontal cortex; MILD COGNITIVE IMPAIRMENT; RANDOMIZED CONTROLLED-TRIAL; NEAR-INFRARED SPECTROSCOPY; HIGH-FREQUENCY STIMULATION; BASAL-GANGLIA; DOPAMINERGIC MODULATION; NEUROPSYCHOLOGICAL CHANGES; FUNCTIONAL-ANATOMY; PREFRONTAL CORTEX; MEDICAL THERAPY;

D O I：

10.1080/13554794.2016.1197951

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). The STN may represent an important relay station not only in the motor but also the associative cortico-striato-thalamocortical pathway. Therefore, STN stimulation may alter cognitive functions, such as working memory (WM). We examined cortical effects of STN-DBS on WM in early PD patients using functional near-infrared spectroscopy. The effects of dopaminergic medication on WM were also examined. Lateral frontal activity during WM maintenance was greater when patients were taking dopaminergic medication. STN-DBS led to a trend-level worsening of WM performance, accompanied by increased lateral frontal activity during WM maintenance. These findings suggest that STN-DBS in PD might lead to functional modifications of the basal ganglia-thalamocortical pathway during WM maintenance.

引用

页码：369 / 378

页数：10

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