Structured interruptions of therapy: looking for the best protocol

被引:10
作者
Aiuti, F [1 ]
Giovannetti, A [1 ]
机构
[1] Univ Roma La Sapienza, Dept Allergy & Clin Immunol, I-00185 Rome, Italy
关键词
HIV; antiretroviral therapy; strategic treatment interruption; drug resistance; immune response;
D O I
10.1097/00002030-200310170-00015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:2257 / 2258
页数:2
相关论文
共 10 条
  • [1] Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virologic, immunologic, and toxicity parameters
    Dybul, M
    Chun, TW
    Yoder, C
    Hidalgo, B
    Belson, M
    Hertogs, K
    Larder, B
    Dewar, RL
    Fox, CH
    Hallahan, CW
    Justement, JS
    Migueles, SA
    Metcalf, JA
    Davey, RT
    Daucher, M
    Pandya, P
    Baseler, M
    Ward, DJ
    Fauci, AS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) : 15161 - 15166
  • [2] A prospective trial of structured treatment interruptions in human immunodeficiency virus infection
    Fagard, C
    Oxenius, A
    Günthard, H
    Garcia, F
    Le Braz, M
    Mestre, G
    Battegay, M
    Furrer, H
    Vernazza, P
    Bernasconi, E
    Telenti, A
    Weber, R
    Leduc, D
    Yerly, S
    Price, D
    Dawson, SJ
    Klimkait, T
    Perneger, TV
    McLean, A
    Clotet, B
    Gatell, JM
    Perrin, L
    Plana, M
    Phillips, R
    Hirschel, B
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (10) : 1220 - 1226
  • [3] Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    Furtado, MR
    Callaway, DS
    Phair, JP
    Kunstman, KJ
    Stanton, JL
    Macken, CA
    Perelson, AS
    Wolinsky, SM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (21) : 1614 - 1622
  • [4] Control of HIV despite the discontinuation of antiretroviral therapy
    Lisziewicz, J
    Rosenberg, E
    Lieberman, J
    Jessen, H
    Lopalco, L
    Siliciano, R
    Walker, B
    Lori, F
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (21) : 1683 - 1684
  • [5] Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
    Miller, V
    Sabin, C
    Hertogs, K
    Bloor, S
    Martinez-Picado, J
    D'Aquila, R
    Larder, B
    Lutz, T
    Gute, P
    Weidmann, E
    Rabenau, H
    Phillips, A
    Staszewski, S
    [J]. AIDS, 2000, 14 (18) : 2857 - 2867
  • [6] Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection
    Oxenius, A
    Price, DA
    Günthard, HF
    Dawson, SJ
    Fagard, C
    Perrin, L
    Fischer, M
    Weber, R
    Plana, M
    García, F
    Hirschel, B
    McLean, A
    Phillips, RE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) : 13747 - 13752
  • [7] Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    Palella, FJ
    Delaney, KM
    Moorman, AC
    Loveless, MO
    Fuhrer, J
    Satten, GA
    Aschman, DJ
    Holmberg, SD
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (13) : 853 - 860
  • [8] Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption
    Papasavvas, E
    Ortiz, GM
    Gross, R
    Sun, JW
    Moore, EC
    Heymann, JJ
    Moonis, M
    Sandberg, JK
    Drohan, LA
    Gallagher, B
    Shull, J
    Nixon, DF
    Kostman, JR
    Montaner, LJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (03) : 766 - 775
  • [9] HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
    Pitcher, CJ
    Quittner, C
    Peterson, DM
    Connors, M
    Koup, RA
    Maino, VC
    Picker, LJ
    [J]. NATURE MEDICINE, 1999, 5 (05) : 518 - 525
  • [10] Immune control of HIV-1 after early treatment of acute infection
    Rosenberg, ES
    Altfeld, M
    Poon, SH
    Phillips, MN
    Wilkes, BM
    Eldridge, RL
    Robbins, GK
    D'Aquila, RT
    Goulder, PJR
    Walker, BD
    [J]. NATURE, 2000, 407 (6803) : 523 - 526