Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

被引：13

作者：

Ramis, Ivy B. ^{[1
]}

Vianna, Julia S. ^{[1
]}

Reis, Ana Julia ^{[1
]}

von Groll, Andrea ^{[1
]}

Ramos, Daniela F. ^{[1
]}

Viveiros, Miguel ^{[2
]}

Almeida da Silva, Pedro E. ^{[1
]}

机构：

[1] Univ Fed Rio Grande, Nucleo Pesquisa Microbiol Med, Rua Gen Osorio,S-N, BR-96201900 Rio Grande, RS, Brazil

[2] Univ Nova Lisboa, Unidade Microbiol Med, GHTM, IHMT, Lisbon, Portugal

来源：

PLANTA MEDICA | 2018年 / 84卷 / 17期

关键词：

usnic acid; verapamil; Mycobacterium abscessus; efflux inhibitor; antimicrobial; RESAZURIN MICROTITER ASSAY; ANTIMYCOBACTERIAL ACTIVITY; SUSCEPTIBILITY; TUBERCULOSIS;

D O I：

10.1055/a-0639-5412

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus. Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine. In conclusion, usnic acid showed both antimicrobial and EI activity, indicating that this natural compound may be a promising scaffold for new drugs against this difficult-to-treat microorganism.

引用

页码：1265 / 1270

页数：6

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